Reduced-dose treatment for relapsed refractory multiple myeloma

Inclusion Criteria:

* Age ≥ 18 years;
* Patients with relapsed/refractory MM, including extramedullary infiltration (meeting IMWG 2016 diagnostic criteria);
* IMWG frailty assessment: frail patients.
* Patients with multiple myeloma who have relapsed after previous treatment with 1-3 regimens;
* Patients unresponsive or unable to undergo autologous stem cell transplantation and with disease progression or resistance after prior treatment with proteasome-containing inhibitors (bortezomib) or immunomodulators (thalidomide, lenalidomide); tolerant to more than one of the above drugs;
* Serum monoclonal protein (M protein) reaches measurable levels: serum M protein ≥ 5 g/L; or 24h urinary light chain \> 200mg; or serum free light chain \> 10mg/dL;
* The patient's clinical indicators must meet the following criteria:ANC ≥ 1.0 x 109/L and PLT ≥ 75 x 109/L for myeloma cells \< 50%; any ANC and PLT ≥ 50 x 109 for myeloma cells ≥ 50%; platelets or granulocyte colony-stimulating factor (G-CSF) may be infused to help patients meet the eligibility criteria, but are not permitted within the first 3 days of enrollment; Patients with a glomerular filtration rate ≥10 mL/min who do not require dialysis;
* Patients who have not undergone major surgery, radiation therapy, or participated in another research trial within 2 weeks and have recovered from clinical toxicity of prior therapy;
* with follow-up conditions. Patients understand the characteristics of the disease they suffer from and voluntarily enroll in this study protocol for treatment and follow-up;
* Informed consent has been signed. Informed consent was signed by the patient himself/herself or his/her immediate family members. From the patient's condition, if the patient's own signature is not conducive to the treatment of the condition, then the legal guardian or the patient's immediate family members will sign the informed consent.

Exclusion Criteria:

* Patients with newly diagnosed multiple myeloma (NDMM), plasma cell leukemia;
* Previous use of pomalidomide, cyclophosphamide;
* patients with cyclophosphamide, dexamethasone allergy/intolerance;
* patients with active hepatitis B (HBV), hepatitis C (HCV), and other acquired and congenital immunodeficiency diseases;
* hepatic insufficiency (bilirubin \> 3.1mg/100m, ALT and AST \> 2 times the upper limit of normal value);
* The presence of severe thrombotic events before treatment;
* Patients with comorbid uncontrolled or severe cardiovascular disease, including myocardial infarction within 6 months prior to enrollment, New York Heart Association (NYHA) defined class III-IV heart failure, uncontrolled angina, clinically significant pericardial disease or cardiac amyloidosis;
* Infection requiring systemic antibiotic therapy, or other serious infection within 14 days;
* Those who underwent major surgery within 30 days prior to enrollment;
* those who require medication for epilepsy, dementia and other abnormal mental conditions who are unable to understand or comply with the study protocol;
* Patients with serious physical or mental illnesses that, in the judgment of the protocol or the investigator, are likely to interfere with participation in this clinical study;
* Substance abuse, medical, psychological, or social conditions that may interfere with the subject's participation in the study or the evaluation of study results;
* persons who, in the opinion of the investigator, are not suitable for enrollment.