Reconstruction of knee osteochondral defects with autologous cartilage or collagen matrix: clinical and MRI outcomes
Descriptive Study of the Reconstruction of Osteochondral Lesions of the Knee: Clinical and Imaging Results
This project will test whether autologous cartilage transplants or collagen knee matrices help adults with osteochondral knee defects and how the repair looks on MRI.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 130 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Versailles Hospital Academic / other |
| Locations | 1 site (Le Chesnay) |
| Trial ID | NCT03908931 on ClinicalTrials.gov |
What this trial studies
Adults who have undergone cartilaginous reconstruction of the knee using either autologous cartilage transplant or a collagen chondro-inducing matrix will be followed for clinical outcomes and MRI imaging. Clinical scores and imaging findings will be collected to describe the quality of repair tissue and patient function. The study excludes other cartilage reconstruction techniques and lesions outside the knee. Results will be reported descriptively to fill gaps in the current literature on these specific reconstruction methods.
Who should consider this trial
Good fit: Adults aged 18 or older with an osteochondral defect of the knee treated with autologous cartilage transplant or a collagen chondro-inducing knee matrix are ideal candidates.
Not a fit: Patients who had other cartilage repair techniques, who have lesions outside the knee, or who are under 18 are unlikely to benefit from this study's findings.
Why it matters
Potential benefit: If successful, the results could help doctors choose reconstruction methods that lead to better knee function and clearer MRI signs of repair.
How similar studies have performed: Similar cartilage transplant and collagen-matrix approaches have shown promising but variable clinical and imaging results, and robust comparative data remain limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * cartilaginous reconstruction by autologous transplant or collagenous chondro-inducing knee matrix * \> 18 years Exclusion Criteria: * Other cartilaginous reconstruction techniques, * other than knee joint
Where this trial is running
Le Chesnay
- CH de Versailles — Le Chesnay, France (Recruiting)
Study contacts
- Study coordinator: Nicolas PUJOL
- Email: npujol@ch-versailles.fr
- Phone: +33139639565
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.