Reconstruction of deficient atrophic ridges using a guide bone regeneration technique
Official title: Reconstruction of Deficient Atrophic Ridges Using Guided Bone Regeneration Technique With Native Collagen Membrane and Polytetrafluoroethylene Membrane (Randomized Clinical Trial)
Run by Cairo University · NCT06746935 · Data updated 2026-11-12
This study tests which type of membrane, either a synthetic or natural one, helps people with bone loss in their jaw grow more bone after surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years to 48 Years |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | Cairo University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Cairo) |
| Status | Recruiting |
| Started | January 1, 2025 |
| Main results expected | June 30, 2025 |
| Study ends | October 29, 2025 |
| Registry record updated | February 19, 2025 |
| Trial ID | NCT06746935 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients with a maxillary residual alveolar bone height of at least 8 mm and width of 5 mm, who have at least one missing tooth and may have experienced previous implant or graft failures.
✕Probably not a fit
Patients who are heavy smokers, have bone diseases affecting healing, or uncontrolled metabolic diseases may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to evaluate the effectiveness of two different membrane types in ridge augmentation procedures for patients with deficient alveolar bone. Participants will be randomly assigned to receive either a Polytetrafluoroethylene membrane or a native collagen membrane after a mixture of autogenous and xenogenic bone is applied. Both groups will undergo diagnostic imaging and surgical procedures, with follow-up imaging conducted four months post-operation to assess outcomes. The study seeks to determine which membrane type yields better bone regeneration results.
Why it matters
Potential benefit: If successful, this study could improve bone regeneration techniques, leading to better outcomes for patients requiring dental implants.
How similar studies have gone: Other studies have shown promising results with similar approaches in bone augmentation, suggesting potential for success in this trial.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with maxillary residual alveolar bone height not less than 8 mm. * Alveolar bone width from less than or equal 5 mm. * Both sexes. * At least missing single tooth. * Previous Failed Implants. * Previous Failed Grafting. Exclusion Criteria: * Heavy smokers more than 20 cigarettes per day. * Patients with bone disease that may affect normal healing, example; hyperparathyroidism. * Patients had radiotherapy and chemotherapy in head and neck. * Patients had neoplasms in sites to be grafted. * Patients with Metabolic diseases uncontrolled diabetic patients, Glycated hemoglobin (Hb A1c) more than 7 mg\\dl.
Where it's running
-
Faculty of Dentistry Cairo University
Cairo, Egypt Recruiting
Study contacts
- Study coordinator: Mohannad A. Ismail, MSc.
- Email: mohannadahmed@hotmail.com
- Phone: +201222968444
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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One-stage ridge splitting in the back lower jaw using two techniques
This compares two surgical methods—piezo surgery versus conventional bone-disc cuts—to widen the narrow back lower jaw so dental implants can be placed in adults with limited ridge width.
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One-stage ridge splitting in the upper jaw using piezo surgery or a bone-disc technique
We will try two ridge-splitting techniques—piezo surgery and bone discs—to widen narrow upper-jaw bone in adults needing a single-tooth implant.
-
Enhanced hydrogel xenograft for open maxillary sinus augmentation
This study tests a hydrogel-enhanced xenograft material to lift the sinus floor during open augmentation and sees if it improves bone formation and tissue response compared with doing the augmentation without graft material.
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Neocement® Inject P for dental bone augmentation and regeneration.
This study will try Neocement® Inject P, an injectable calcium‑phosphate bone substitute, in adults having reconstructive dental or maxillofacial surgery to see if it is safe and helps bone heal.
-
Neobone® safety and performance in dental bone grafting
This project will collect real-world data to see if Neobone® is safe and helps bone heal in adults having reconstructive dental procedures.
-
Bone grafting at implant removal to help success of putting a new implant in the same spot
This study tests whether doing bone grafting at the same time as removing a failed dental implant helps people who plan to get a new implant in the same location.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.