Clinical trial Recruiting at 1 site Interventional Ages 20 to 48

Reconstruction of deficient atrophic ridges using a guide bone regeneration technique

Official title: Reconstruction of Deficient Atrophic Ridges Using Guided Bone Regeneration Technique With Native Collagen Membrane and Polytetrafluoroethylene Membrane (Randomized Clinical Trial)

Run by Cairo University · NCT06746935 · Data updated 2026-11-12

This study tests which type of membrane, either a synthetic or natural one, helps people with bone loss in their jaw grow more bone after surgery.

Quick facts

Study typeInterventional
Ages20 Years to 48 Years
SexAll
Enrollment20 (estimated)
SponsorCairo University
Academic / other
Drugs / interventionschemotherapy
Locations1 site (Cairo)
StatusRecruiting
StartedJanuary 1, 2025
Main results expectedJune 30, 2025
Study endsOctober 29, 2025
Registry record updatedFebruary 19, 2025
Trial IDNCT06746935 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include patients with a maxillary residual alveolar bone height of at least 8 mm and width of 5 mm, who have at least one missing tooth and may have experienced previous implant or graft failures.

Probably not a fit

Patients who are heavy smokers, have bone diseases affecting healing, or uncontrolled metabolic diseases may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness of two different membrane types in ridge augmentation procedures for patients with deficient alveolar bone. Participants will be randomly assigned to receive either a Polytetrafluoroethylene membrane or a native collagen membrane after a mixture of autogenous and xenogenic bone is applied. Both groups will undergo diagnostic imaging and surgical procedures, with follow-up imaging conducted four months post-operation to assess outcomes. The study seeks to determine which membrane type yields better bone regeneration results.

Why it matters

Potential benefit: If successful, this study could improve bone regeneration techniques, leading to better outcomes for patients requiring dental implants.

How similar studies have gone: Other studies have shown promising results with similar approaches in bone augmentation, suggesting potential for success in this trial.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients with maxillary residual alveolar bone height not less than 8 mm.
* Alveolar bone width from less than or equal 5 mm.
* Both sexes.
* At least missing single tooth.
* Previous Failed Implants.
* Previous Failed Grafting.

Exclusion Criteria:

* Heavy smokers more than 20 cigarettes per day.
* Patients with bone disease that may affect normal healing, example; hyperparathyroidism.
* Patients had radiotherapy and chemotherapy in head and neck.
* Patients had neoplasms in sites to be grafted.
* Patients with Metabolic diseases uncontrolled diabetic patients, Glycated hemoglobin (Hb A1c) more than 7 mg\\dl.

Where it's running

  • Faculty of Dentistry Cairo University
    Cairo, Egypt
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.