Reconstructing the jawbone using a new vascular technique
Official title: Mandibular Reconstruction Using Tissue Regeneration With Axially Vascularised Bone Substitutes
Run by University of Alexandria · NCT04001842 · Data updated 2026-11-12
This study is testing a new way to rebuild the jawbone for patients with serious injuries or conditions to see if it helps the bone heal better and faster.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 10 (estimated) |
| Sponsor | University of Alexandria Academic / other |
| Locations | 1 site (Alexandria) |
| Status | Recruiting |
| Started | July 1, 2019 |
| Main results expected | June 30, 2029 |
| Study ends | June 30, 2030 |
| Registry record updated | December 5, 2024 |
| Trial ID | NCT04001842 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are middle-aged adults (18-65 years) with mandibular defects of 6 cm or more that are tumor-free.
✕Probably not a fit
Patients under 18 or over 65 years old, or those with uncontrolled chronic illnesses, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study focuses on reconstructing the mandible in patients with significant defects due to trauma, tumors, or infections. It employs a novel approach using axially vascularized bone substitutes, which aims to enhance blood supply to the reconstructed tissue through a microvascular arteriovenous loop. The study seeks to evaluate the effectiveness of this technique in promoting successful healing and integration of the bone substitute in the craniofacial region. By addressing the challenges of vascularization in large defects, this approach could potentially reduce complications associated with traditional reconstruction methods.
Why it matters
Potential benefit: If successful, this technique could lead to improved healing and functional outcomes for patients requiring jaw reconstruction.
How similar studies have gone: While similar techniques have shown promise in case reports, this specific application in the craniofacial region is novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients requiring mandibular reconstruction for further dental rehabilitation * Mandibular defect (marginal/segmental) equals or more than 6 cm in largest dimension * Middle age adult (18-65 years) * Radiologically and pathologically documented tumour free mandibular defect Exclusion Criteria: * Extremes of age (\<18 or \> 65 years) * Associated uncontrolled chronic illness (Diabetes mellitus, Hypertension, Rheumatoid arthritis, collagen disease, Chronic obstructive pulmonary disease) * Primary reconstruction of a mandibular defect after tumour excision
Where it's running
-
Faculty of Medicine, University of Alexandria
Alexandria, Egypt Recruiting
Study contacts
- Study coordinator: Ahmad M Eweida, MD, PhD
- Email: ahmad.eweida@alexmed.edu.eg
- Phone: 0049 017665232331
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.