Rebuilding the gum papilla with three methods
Official title: Restoring Lost Pink Triangle by Comparing Three Different Papillary Reconstruction Modalities: A Randomized Clinical Trial
Run by Mansoura University · NCT07159802 · Data updated 2026-11-12
This study will try three ways—hyaluronic acid injections (with possible booster doses), slow-resorbing ALB-PRF injections, and a minimally invasive modified Beagle surgery—to restore lost interdental papilla in adults with class 1–2 papilla defects.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years to 50 Years |
| Sex | All |
| Enrollment | 24 (estimated) |
| Sponsor | Mansoura University Academic / other |
| Locations | 1 site (Al Mansurah, Dakahlia Governorate) |
| Status | Recruiting |
| Started | February 25, 2025 |
| Main results expected | April 25, 2026 |
| Study ends | April 30, 2026 |
| Registry record updated | September 8, 2025 |
| Trial ID | NCT07159802 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 20–50 with class 1 or 2 interdental papilla loss, a minimum of 3 mm attached gingiva, and stage 1–2 periodontitis who are non-smokers and can maintain oral hygiene are ideal candidates.
✕Probably not a fit
Patients with stage 3–4 periodontitis, smokers, those with chronic systemic diseases, high frenum attachment, diastema, pregnancy or lactation, or inadequate attached gingiva are unlikely to receive benefit from these procedures.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Participants with class 1–2 interdental papilla loss will receive one of three reconstruction techniques at a single center: hyaluronic acid injections with booster doses as needed, autologous lyophilized platelet-rich fibrin (ALB-PRF) injections intended for a slower resorption and longer effect, or a minimally invasive surgical repair modified from Beagle's technique. Treatments will be performed according to a standardized protocol and patients will be followed to document papilla fill, aesthetic outcomes, and any complications. Eligible participants are adults 20–50 years old with at least 3 mm of attached gingiva and stage 1–2 periodontitis, while smokers and those with systemic disease or other exclusions are not eligible. The trial compares clinical durability and patient-reported aesthetic results across the three modalities at Mansoura University.
Why it matters
Potential benefit: If successful, one of these methods could offer a more reliable, longer-lasting, and less invasive way to rebuild the interdental papilla and improve smile appearance.
How similar studies have gone: Small clinical reports and case series have reported promising results for hyaluronic acid and PRF in soft-tissue papillary augmentation and mixed outcomes for surgical methods, but direct head-to-head comparisons of all three approaches are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 1\. Age: 20 to 50 years. 2. Class 1 and 2 inter dental papilla loss according to Nordland \& Tarnow classification (17). 3\. Adequate attached gingiva (minimum 3 mm). 4. Stage 1or 2 periodontitis (18). Exclusion Criteria: * 1\. Smokers. 2. Chronic systemic diseases. 3. Drug usage. 4. High frenum attachment. 5. Diastema. 6. Pregnancy and lactation. 7. Stage 3 \& 4 periodontitis (18). 8. Noncompliance with oral hygiene measures.
Where it's running
-
Mansoura University
Al Mansurah, Dakahlia Governorate, Egypt Recruiting
Study contacts
- Principal investigator: Tasneem E Abdallah, BDS — Mansoura University
- Study coordinator: Tasneem E Abdallah, BDS
- Email: tasneemehabgamal@mans.edu.eg
- Phone: 01097217205
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.