Real-world comparison of drugs used to treat Familial Mediterranean Fever

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This retrospective observational project collects medical records from patients with a clinical FMF diagnosis (Tel Hashomer criteria) treated at Tongji Hospital to compare effectiveness and safety of drugs used in routine care. Investigators will extract treatment regimens, attack frequency and severity, laboratory markers, and adverse events to summarize outcomes across drug types. Patients with severe organ dysfunction, active severe infection, pregnancy, substance dependence, or conditions requiring immunosuppression are excluded. The study is coordinated by Tongji Hospital with collaborators at Union Hospital, Huazhong University of Science and Technology, Pfizer, and Johns Hopkins to analyze real-world treatment patterns.

Why it matters

Who can join: the full rules

Inclusion Criteria:

\- Clinical diagnosis of Familial Mediterranean fever (FMF) patients (Tel Hashomer criteria)

Exclusion Criteria:

* Have a history of mental illness, or alcohol and drug dependence；
* Pregnant, with severe infection, severe cardiac insufficiency, severe liver or kidney dysfunction；
* Complicated with tumors, organ transplants, etc. which have significant impact on the immune system or require the use of immunosuppressants.

Where it's running

• Tongji Hospital
  Wuhan, Hubei, China Recruiting

Study contacts

• Study coordinator: Yikai Yu
• Email: yuyikai@163.com
• Phone: 86-027-83665519

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Low-Calorie Diet in adolescents with Familial Mediterranean Fever and metabolic syndrome

  A group of adolescents with both FMF and metabolic syndrome will try a low-calorie diet for 3 months to see if it helps manage metabolic symptoms.

  Recruiting Cairo University · Giza, Dokki · NCT07833007

• Exploring genetics and characteristics of familial Mediterranean fever and related disorders

  This study is trying to understand the genetics and symptoms of diseases that cause fever, like familial Mediterranean fever, by looking at patients, their families, and healthy volunteers.

  Recruiting National Institutes of Health Clinical Center (CC) · Washington D.C., District of Columbia and 4 other locations · NCT00001373

• Canakinumab use in FMF and Still's disease patients across real-world care

  This real-world study looks at how people with FMF or Still's disease who were treated with canakinumab fare over at least 6 months.

  Recruiting Novartis · Basel · NCT07517250

• Mediterranean diet with or without aerobic exercise for women with familial Mediterranean fever and fatty liver

  This trial will test whether adding regular aerobic exercise to a Mediterranean diet helps women with familial Mediterranean fever who have non-alcoholic fatty liver disease.

  Recruiting Cairo University · Dokki, Giza Governorate · NCT07130318

• Whole-body vibration plus vitamin D for adolescent girls with familial Mediterranean fever

  This project will try adding regular whole-body vibration sessions to vitamin D and usual colchicine for girls aged 13–17 with familial Mediterranean fever to see if it improves fitness, muscle strength, and bone mass.

  Recruiting Cairo University · Giza, Dokki · NCT07130305

• Inspiratory muscle training for adolescents with Familial Mediterranean Fever

  This trial will try a daily inspiratory muscle training program to see if it improves breathing strength, exercise tolerance, and fatigue in teenagers (ages 13–17) with Familial Mediterranean Fever who are taking colchicine.

  Recruiting Cairo University · Giza, Dokki · NCT07129538

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.