Real-time imaging of normal throat and larynx motion during a barium swallow
Official title: Observational Imaging Study on Real-Time Dynamic Changes of Normal Pharyngolaryngeal Structures During Barium Swallow in Patients Undergoing Routine Barium Meal Examination
Run by Zhejiang Cancer Hospital · NCT07264322 · Data updated 2026-11-12
This project will record routine barium-swallow X-rays to see how normal throat and voice-box structures move in adults.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 3 (estimated) |
| Sponsor | Zhejiang Cancer Hospital Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Hangzhou, Zhejiang) |
| Status | Recruiting |
| Started | September 10, 2025 |
| Main results expected | December 30, 2025 |
| Study ends | December 30, 2025 |
| Registry record updated | December 4, 2025 |
| Trial ID | NCT07264322 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–75 who are already scheduled for a routine barium meal exam and have normal pharyngolaryngeal anatomy and no swallowing dysfunction are ideal candidates.
✕Probably not a fit
People with prior pharyngolaryngeal surgery, anatomical abnormalities, compressive lesions, swallowing disorders, or barium allergy are unlikely to benefit from this imaging-only project.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational project uses de-identified images from routine barium meal examinations at Zhejiang Cancer Hospital to capture both static and real-time dynamic views of the pharyngolaryngeal region. Participants will undergo standard clinical static imaging at rest and dynamic imaging while swallowing measured volumes of barium (5, 10, 20, 40 ml) with a digital X-ray system. Only patients aged 18–75 with normal pharyngolaryngeal anatomy and unobstructed swallowing will be included, and no extra procedures or radiation beyond standard care are required. The recorded movement patterns will be analyzed to provide anatomical and physiological data relevant to laryngeal mask design and fit.
Why it matters
Potential benefit: If successful, the findings could help improve the anatomical fit and safety of laryngeal masks used for airway management.
How similar studies have gone: Fluoroscopic and videofluoroscopic swallowing studies are well-established for characterizing swallowing mechanics, but using those measurements specifically to guide laryngeal mask design is a relatively novel application.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 18-75 years; * No history of pharyngolaryngeal surgery, trauma, or congenital malformation; * No swallowing dysfunction, pharyngolaryngeal inflammation, or neurological diseases affecting swallowing; * No recent use of drugs that affect muscle function (e.g., muscle relaxants, anticholinergics); * Barium meal examination confirms unobstructed oropharyngeal-esophageal pathway; * Normal pharyngolaryngeal anatomical structure (confirmed by preliminary imaging review); * Scheduled to undergo routine barium meal examination at Zhejiang Cancer Hospital for clinical diagnosis. Exclusion Criteria: * Presence of diseases that may compress pharyngolaryngeal structures (e.g., goiter, mediastinal mass); * Allergy to barium sulfate or other components of the barium suspension.
Where it's running
-
Jiangling Wang
Hangzhou, Zhejiang, China Recruiting
Study contacts
- Study coordinator: Xiaochun Jin, M.D
- Email: ec@zjcc.org.cn
- Phone: +86 571 88122564
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.