Real-time imaging of normal throat and larynx motion during a barium swallow
Observational Imaging Study on Real-Time Dynamic Changes of Normal Pharyngolaryngeal Structures During Barium Swallow in Patients Undergoing Routine Barium Meal Examination
This project will record routine barium-swallow X-rays to see how normal throat and voice-box structures move in adults.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 3 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | Zhejiang Cancer Hospital Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Hangzhou, Zhejiang) |
| Trial ID | NCT07264322 on ClinicalTrials.gov |
What this trial studies
This observational project uses de-identified images from routine barium meal examinations at Zhejiang Cancer Hospital to capture both static and real-time dynamic views of the pharyngolaryngeal region. Participants will undergo standard clinical static imaging at rest and dynamic imaging while swallowing measured volumes of barium (5, 10, 20, 40 ml) with a digital X-ray system. Only patients aged 18–75 with normal pharyngolaryngeal anatomy and unobstructed swallowing will be included, and no extra procedures or radiation beyond standard care are required. The recorded movement patterns will be analyzed to provide anatomical and physiological data relevant to laryngeal mask design and fit.
Who should consider this trial
Good fit: Adults aged 18–75 who are already scheduled for a routine barium meal exam and have normal pharyngolaryngeal anatomy and no swallowing dysfunction are ideal candidates.
Not a fit: People with prior pharyngolaryngeal surgery, anatomical abnormalities, compressive lesions, swallowing disorders, or barium allergy are unlikely to benefit from this imaging-only project.
Why it matters
Potential benefit: If successful, the findings could help improve the anatomical fit and safety of laryngeal masks used for airway management.
How similar studies have performed: Fluoroscopic and videofluoroscopic swallowing studies are well-established for characterizing swallowing mechanics, but using those measurements specifically to guide laryngeal mask design is a relatively novel application.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged 18-75 years; * No history of pharyngolaryngeal surgery, trauma, or congenital malformation; * No swallowing dysfunction, pharyngolaryngeal inflammation, or neurological diseases affecting swallowing; * No recent use of drugs that affect muscle function (e.g., muscle relaxants, anticholinergics); * Barium meal examination confirms unobstructed oropharyngeal-esophageal pathway; * Normal pharyngolaryngeal anatomical structure (confirmed by preliminary imaging review); * Scheduled to undergo routine barium meal examination at Zhejiang Cancer Hospital for clinical diagnosis. Exclusion Criteria: * Presence of diseases that may compress pharyngolaryngeal structures (e.g., goiter, mediastinal mass); * Allergy to barium sulfate or other components of the barium suspension.
Where this trial is running
Hangzhou, Zhejiang
- Jiangling Wang — Hangzhou, Zhejiang, China (Recruiting)
Study contacts
- Study coordinator: Xiaochun Jin, M.D
- Email: ec@zjcc.org.cn
- Phone: +86 571 88122564
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.