Real-time imaging for monitoring proton therapy in prostate cancer
UFPTI 2403-PR12: Real-Time Volumetric Ionizing Radiation Acoustic Imaging for In-vivo Proton Treatment Monitoring in Pencil-Beam Scanning
This study is testing a new imaging technique to see if it can help doctors better monitor proton therapy for patients with prostate cancer during their treatment.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 100 Years |
| Sex | Male |
| Sponsor | University of Florida Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Jacksonville, Florida) |
| Trial ID | NCT06465966 on ClinicalTrials.gov |
What this trial studies
This study evaluates the use of ionizing-radiation photo acoustic imaging (iRAI) to monitor proton radiation treatment in patients with prostate cancer. The approach involves utilizing advanced imaging techniques to provide real-time feedback during treatment, potentially improving the accuracy and effectiveness of proton therapy. Eligible patients will receive proton radiation therapy while their treatment is monitored using iRAI technology. The study aims to assess the feasibility and benefits of this innovative imaging method in enhancing treatment outcomes.
Who should consider this trial
Good fit: Ideal candidates are patients diagnosed with prostate cancer who meet specific size and weight criteria for treatment.
Not a fit: Patients with significant medical implants in the treatment area or those who are uncomfortable with the imaging process may not benefit from this study.
Why it matters
Potential benefit: If successful, this could lead to more precise and effective proton therapy for prostate cancer patients.
How similar studies have performed: While the use of imaging techniques in radiation therapy is established, the specific application of iRAI for proton treatment monitoring is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Disease: Prostate cancer * Treatment site: * Prostate or prostate and seminal vesicle * No regional lymph node is involved * Patient's body weight: Patient's body weight is less than 350 lbs to consider the total weight limit that the ProteusONE treatment table and the robotic arm can operate * Treatment volume size: maximum size less than 15 x 15 cm in a cross-section and a thickness less than 20 cm to consider 2D transducer matrix size * Provision to sign the consent form and understand the non-invasiveness of iRAI * Patient agreement on tolerance on placing a water bag to acquire iRAI during treatment * Treatment modality: Proton radiation therapy with UFHPTI's ProteusONE gantry using PBS Exclusion Criteria: * A patient who would not be tolerable or will feel nervous about being touched on the skin with a water bag * A patient with a significant medical implant or hardware in the treatment area
Where this trial is running
Jacksonville, Florida
- Univeristy of Florida Health Proton Therapy Institute — Jacksonville, Florida, United States (Recruiting)
Study contacts
- Study coordinator: Jiyeon Park
- Email: jpark@floridaproton.org
- Phone: 904-588-1800
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.