Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Real-time imaging for lung cancer radiotherapy

Official title: Respiratory Adaptive Computed Tomography: A Pilot Feasibility Study on the Use of Real-Time Gated 4DCT for Lung Cancer Radiation Therapy

Run by University of Sydney · NCT05030207 · Data updated 2026-11-12

This study is testing if a new type of real-time imaging can help lung cancer patients get better radiotherapy by improving how accurately doctors can see and target tumors during treatment.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment30 (estimated)
SponsorUniversity of Sydney
Academic / other
Drugs / interventionsradiation
Locations1 site (Blacktown, New South Wales)
StatusRecruiting
StartedMay 15, 2024
Main results expectedDecember 2026
Study endsDecember 2026
Registry record updatedMay 19, 2026
Trial IDNCT05030207 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 and older diagnosed with lung cancer who require radiation therapy and can provide informed consent.

Probably not a fit

Patients who are pregnant or unable to tolerate the additional time required for the extra scan may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the feasibility of using Real-Time Gated 4DCT imaging in lung cancer patients undergoing radiotherapy. Participants will receive an additional 4DCT scan alongside the standard imaging procedure to assess the impact of real-time gating on image quality and treatment planning. The study will randomize the order of the scans to compare the conventional 4DCT with the gated version. The goal is to improve the accuracy of tumor localization and minimize errors caused by irregular breathing during imaging.

Why it matters

Potential benefit: If successful, this approach could enhance the precision of lung cancer radiotherapy, potentially improving treatment outcomes.

How similar studies have gone: While the use of 4DCT is standard in radiotherapy, the specific application of Real-Time Gated 4DCT is relatively novel and has not been extensively tested in prior studies.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* 18 years or older
* Have the ability to give informed consent
* A diagnosis of lung cancer with an indication for radiation therapy
* Radiation therapy treatment involving the acquisition of a 4DCT scan for treatment planning

Exclusion Criteria:

* Pregnant women
* Patients \<18 years
* Patients who in the opinion of the treating physician could not tolerate the extra time on the CT couch for an extra scan

Where it's running

  • Blacktown Hospital
    Blacktown, New South Wales, Australia
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.