Real-time imaging for lung cancer radiotherapy
Respiratory Adaptive Computed Tomography: A Pilot Feasibility Study on the Use of Real-Time Gated 4DCT for Lung Cancer Radiation Therapy
This study is testing if a new type of real-time imaging can help lung cancer patients get better radiotherapy by improving how accurately doctors can see and target tumors during treatment.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Sydney Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Blacktown, New South Wales) |
| Trial ID | NCT05030207 on ClinicalTrials.gov |
What this trial studies
This study evaluates the feasibility of using Real-Time Gated 4DCT imaging in lung cancer patients undergoing radiotherapy. Participants will receive an additional 4DCT scan alongside the standard imaging procedure to assess the impact of real-time gating on image quality and treatment planning. The study will randomize the order of the scans to compare the conventional 4DCT with the gated version. The goal is to improve the accuracy of tumor localization and minimize errors caused by irregular breathing during imaging.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older diagnosed with lung cancer who require radiation therapy and can provide informed consent.
Not a fit: Patients who are pregnant or unable to tolerate the additional time required for the extra scan may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance the precision of lung cancer radiotherapy, potentially improving treatment outcomes.
How similar studies have performed: While the use of 4DCT is standard in radiotherapy, the specific application of Real-Time Gated 4DCT is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years or older * Have the ability to give informed consent * A diagnosis of lung cancer with an indication for radiation therapy * Radiation therapy treatment involving the acquisition of a 4DCT scan for treatment planning Exclusion Criteria: * Pregnant women * Patients \<18 years * Patients who in the opinion of the treating physician could not tolerate the extra time on the CT couch for an extra scan
Where this trial is running
Blacktown, New South Wales
- Blacktown Hospital — Blacktown, New South Wales, Australia (Recruiting)
Study contacts
- Principal investigator: Ricky O'Brien, PhD — University of Sydney
- Study coordinator: Shona J Silvester, MMedSc
- Email: Shona.Silvester@sydney.edu.au
- Phone: +61286271185
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.