Re-infusion of unwashed shed blood during off-pump coronary artery surgery
Isolated Cardiotomy Circuit for Re-infusion of Unwashed Shed Blood During Off-pump Coronary Artery Surgery
This study tests whether re-infusing unwashed blood during heart surgery can improve recovery and outcomes for patients compared to standard methods.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 40 Years to 75 Years |
| Sex | All |
| Sponsor | Damascus University Academic / other |
| Locations | 1 site (Damascus) |
| Trial ID | NCT06358079 on ClinicalTrials.gov |
What this trial studies
This study evaluates the efficacy and side effects of re-infusing unwashed shed blood during off-pump coronary artery bypass surgery using a novel cardiotomy circuit. It aims to compare clinical outcomes, transfusion requirements, inflammatory responses, and cognitive status between patients receiving this intervention and those undergoing conventional techniques. The study will involve randomizing participants into two groups, with one group receiving the experimental treatment and the other following standard care. The research is set to take place at Damascus University Cardiac Surgery Hospital over a two-year period.
Who should consider this trial
Good fit: Ideal candidates are patients aged 40 to 75 undergoing isolated off-pump coronary artery bypass surgery.
Not a fit: Patients with impaired left ventricular function, renal or hepatic failure, or those requiring emergency operations may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could reduce the need for blood transfusions and associated complications during cardiac surgery.
How similar studies have performed: While the use of auto-transfusion techniques has been explored, this specific approach using an isolated cardiotomy circuit is relatively novel and has limited prior data.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients undergoing isolated off-pump coronary artery bypass surgery between March 1st, 2024 and March 31st, 2026. Exclusion Criteria: * Missing data. * Patients outside the study period. * Patients under the age of 40 years or over the age of 75 years. * Patients with impaired left ventricular function (EF less the 40%). * Patients with history of renal failure, hepatic failure, CVA, or TIA. * Patients who have not stopped anticoagulants (except aspirin) for 4 days preoperatively. * Emergency operations.
Where this trial is running
Damascus
- Damascus University Cardiac Surgery Hospital — Damascus, Syrian Arab Republic (Recruiting)
Study contacts
- Study coordinator: Albaraa Bara, MD
- Email: mbizzat@damascusuniversity.edu.sy
- Phone: 0934206291
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.