Rapid immune effects of Agaricus, Reishi, and Turkey Tail mushrooms

Clinical Trail: Rapid Immune Modulating Effects

This study will test whether taking Agaricus, Reishi, or Turkey Tail mushrooms changes immune activity in healthy adults.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 12 (estimated)
• Ages: 18 Years to 75 Years
• Sex: All
• Sponsor: Natural Immune Systems Inc (Academic / other)
• Locations: 1 site (Klamath Falls, Oregon)
• Trial ID: NCT07195552 on ClinicalTrials.gov

What this trial studies

This interventional trial compares acute immune responses after ingestion of three medicinal mushrooms (Agaricus, Reishi, and Turkey Tail) versus a placebo in healthy adults aged 18–75. Participants follow a controlled routine and undergo multiple blood draws to measure pro- and anti-inflammatory cytokines, markers of immune cell activation, and immune cell trafficking related to circadian cycles. The protocol excludes people with major gastrointestinal surgery, those on daily anti-inflammatory medications, individuals undergoing intensive athletic training, and those experiencing major life stress. All visits take place at NIS Labs in Klamath Falls, Oregon.

Who should consider this trial

Good fit: Healthy adults aged 18–75 with visible veins in one or both arms who can follow the study's diet, activity, and clinic-visit rules are the intended participants.

Not a fit: People with prior major GI surgery, those taking daily anti-inflammatory medications, currently undergoing intensive athletic training, or experiencing major stress are unlikely to benefit from this protocol.

Why it matters

Potential benefit: If successful, the trial could show these mushroom supplements temporarily boost immune signaling and surveillance in healthy adults, informing nutraceutical use.

How similar studies have performed: Some prior studies of medicinal mushroom extracts have shown short-term immune-modulating effects, but results are mixed and often small-scale.

Eligibility criteria

Inclusion Criteria:

* Healthy adults;
* Age 18-75 years (inclusive);
* Veins easy to see in one or both arms (to allow for the multiple blood draws);
* Willing to comply with study procedures, including:
* Maintaining a consistent diet and lifestyle routine throughout the study,
* Consistent habit of bland breakfasts on days of clinic visits,
* Abstaining from exercising and nutritional supplements on the morn ing of a study visit,
* Abstaining from use of coffee, tea, and soft drinks for at least one hour prior to a clinic visit;
* Abstaining from music, candy, gum, computer/cell phone use, during clinic visits.

Exclusion Criteria:

* Previous major gastrointestinal surgery (absorption of test product may be altered) (minor surgery not a problem, including previous removal of appendix and gall bladder);
* Taking anti-inflammatory medications on a daily basis;
* Currently experiencing intense stressful events/ life changes;
* Currently in intensive athletic training (such as marathon runners);
* Currently taking antipsychotic medications such as clozapine, Risperdal, Abilify, Zyprexa or Seroquel;
* An unusual sleep routine (examples: working graveyard shift, irregular routine with frequent late nights, studying, partying);
* Unwilling to maintain a constant intake of supplements over the duration of the study;
* Anxiety about having blood drawn;
* Pregnant, nursing, or trying to become pregnant;
* Known food allergies related to ingredients in active test product or placebo.

Where this trial is running

Klamath Falls, Oregon

• NIS Labs — Klamath Falls, Oregon, United States (Recruiting)

Study contacts

• Study coordinator: Gitte S Jensen, PhD

Conditions Immune Surveillance