Rapid identification of microbial species and antibiotic resistance in emergency department patients with infections
Official title: Clinical Microbial Species and Antibiotic Resistance Identification in Patients Presenting to the Emergency Department With Three of Four Systemic Inflammatory Response Syndrome (SIRS) Criteria - is Rapid Identification Possible and Accurate?
Run by Michigan State University · NCT01904188 · Data updated 2026-11-12
This study is testing new ways to quickly identify germs and their resistance to antibiotics in patients with infections in the emergency department to help doctors treat them better and faster.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 2500 (estimated) |
| Sponsor | Michigan State University Academic / other |
| Locations | 2 sites (Lansing, Michigan and 1 other locations) |
| Status | Recruiting |
| Started | June 2015 |
| Main results expected | July 2030 |
| Study ends | July 2032 |
| Registry record updated | June 8, 2026 |
| Trial ID | NCT01904188 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adult patients exhibiting three of four systemic inflammatory response syndrome characteristics and suspected of having sepsis.
✕Probably not a fit
Patients who do not meet the SIRS criteria or are pediatric may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This project aims to evaluate the effectiveness of new rapid identification techniques for microbial pathogens in patients presenting with suspected infections or sepsis. By utilizing advanced diagnostic methods developed in the lab, the study will analyze bodily fluid samples to determine the accuracy and timeliness of identifying pathogens and their antibiotic resistance. The goal is to improve patient outcomes through faster diagnosis and targeted treatment, particularly for those exhibiting signs of systemic inflammatory response syndrome. Specimens will be collected from patients at participating hospitals and analyzed to assess the potential of these new technologies in clinical settings.
Why it matters
Potential benefit: If successful, this study could lead to faster and more accurate diagnoses of infections, improving treatment outcomes for patients with sepsis.
How similar studies have gone: Other studies have shown promise in using rapid diagnostic techniques for microbial identification, indicating potential success for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Adult patients with 3 of 4 systemic inflammatory response syndrome (SIRS) characteristics (1. tachycardia, 2. fever or hypothermia, 3. tachypnea, 4. leukocytosis), who have blood cultures drawn and/or urine collected for the evaluation of suspected sepsis, and/or other bodily fluids collected for culture and sensitivity analysis. Patients with other sources of infection with less than 3 of 4 SIRS criteria including sputum, wound drainage, CSF, nasal or oral secretions. Exclusion Criteria: Pediatric patients
Where it's running
-
University of Michigan Health/Sparrow (name change only)
Lansing, Michigan, United States Recruiting -
McLaren Greater Lansing
Lansing, Michigan, United States Recruiting
Study contacts
- Principal investigator: Mary J Hughes, DO — Michigan State University
- Study coordinator: Mary J Hughes, DO
- Email: hughesm@msu.edu
- Phone: 517-353-3211
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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This study is trying to find out if certain immune responses can help doctors spot sepsis in patients with infections when they arrive at the emergency room.
-
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This study is testing a faster way to diagnose sepsis in newborns and children by using a new blood test to see if it can identify infections more quickly than the usual method.
-
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-
Using blood purification therapy for critically ill patients
This study is trying to see which critically ill patients can benefit the most from a special blood purification treatment to help improve their recovery from serious conditions like kidney injury and sepsis.
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Evaluating blood purification therapies in critically ill patients
This study is testing if certain blood purification treatments can help critically ill patients with kidney problems or multiple organ failure feel better and recover faster.
-
Ruta C and Vitamin C in Sepsis: Adding antioxidants to standard care
This trial tests whether adding Ruta C (rutin plus vitamin C) or vitamin C alone to standard sepsis treatment helps adults in the ICU stay shorter and recover better.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.