Rapid identification of microbial species and antibiotic resistance in emergency department patients with infections
Clinical Microbial Species and Antibiotic Resistance Identification in Patients Presenting to the Emergency Department With Three of Four Systemic Inflammatory Response Syndrome (SIRS) Criteria - is Rapid Identification Possible and Accurate?
This study is testing new ways to quickly identify germs and their resistance to antibiotics in patients with infections in the emergency department to help doctors treat them better and faster.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2500 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Michigan State University Academic / other |
| Locations | 2 sites (Lansing, Michigan and 1 other locations) |
| Trial ID | NCT01904188 on ClinicalTrials.gov |
What this trial studies
This project aims to evaluate the effectiveness of new rapid identification techniques for microbial pathogens in patients presenting with suspected infections or sepsis. By utilizing advanced diagnostic methods developed in the lab, the study will analyze bodily fluid samples to determine the accuracy and timeliness of identifying pathogens and their antibiotic resistance. The goal is to improve patient outcomes through faster diagnosis and targeted treatment, particularly for those exhibiting signs of systemic inflammatory response syndrome. Specimens will be collected from patients at participating hospitals and analyzed to assess the potential of these new technologies in clinical settings.
Who should consider this trial
Good fit: Ideal candidates for this study are adult patients exhibiting three of four systemic inflammatory response syndrome characteristics and suspected of having sepsis.
Not a fit: Patients who do not meet the SIRS criteria or are pediatric may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to faster and more accurate diagnoses of infections, improving treatment outcomes for patients with sepsis.
How similar studies have performed: Other studies have shown promise in using rapid diagnostic techniques for microbial identification, indicating potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Adult patients with 3 of 4 systemic inflammatory response syndrome (SIRS) characteristics (1. tachycardia, 2. fever or hypothermia, 3. tachypnea, 4. leukocytosis), who have blood cultures drawn and urine collected for the evaluation of suspected sepsis, and/or other bodily fluids collected for culture and sensitivity analysis. Patients with other sources of infection with less than 3 of 4 SIRS criteria Exclusion Criteria: Pediatric patients
Where this trial is running
Lansing, Michigan and 1 other locations
- University of Michigan Health/Sparrow (name change only) — Lansing, Michigan, United States (Recruiting)
- McLaren Greater Lansing — Lansing, Michigan, United States (Recruiting)
Study contacts
- Principal investigator: Mary J Hughes, DO — Michigan State University
- Study coordinator: Mary J Hughes, DO
- Email: hughesm@msu.edu
- Phone: 517-353-3211
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.