Rapid effects of four products on stem cells, immunity, and cellular energy
Official title: Rapid Response of Stem Cells and Immune Cells for Efficacy: An Acute Randomized Double-blind Placebo-controlled Cross-over Trial
Run by Natural Immune Systems Inc · NCT07127705 · Data updated 2026-11-12
This trial will test whether taking four different products causes rapid changes in stem cell surveillance, immune activation, and mitochondrial energy in healthy adults aged 18 to 75.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 24 (estimated) |
| Sponsor | Natural Immune Systems Inc Academic / other |
| Locations | 1 site (Klamath Falls, Oregon) |
| Status | Recruiting |
| Started | May 21, 2025 |
| Main results expected | August 27, 2025 |
| Study ends | October 3, 2025 |
| Registry record updated | August 17, 2025 |
| Trial ID | NCT07127705 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Healthy adults aged 18 to 75 with BMI 18.0–34.9, easily visible arm veins, and willingness to follow study diet and clinic visit rules are ideal candidates.
✕Probably not a fit
People with prior major gastrointestinal surgery, daily anti-inflammatory medication use, or other exclusion criteria are not eligible and unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This double-blind, placebo-controlled, crossover trial gives each healthy participant four test products and a placebo on separate visits with multiple blood draws to measure immediate responses. Researchers will track stem cell trafficking in the blood and measure mitochondrial energy production and resilience in white blood cells exposed to oxidative and inflammatory stress ex vivo. The products tested are chaga mushroom, ginseng extract, olive extract, and potassium hydrogen glucarate. Participants must follow specific pre-visit routines and have easily accessible veins for repeated blood sampling.
Why it matters
Potential benefit: If successful, these products could offer a simple, fast-acting way to support stem cell surveillance and mitochondrial energy, which may improve immune and recovery responses.
How similar studies have gone: Laboratory and some clinical work suggest natural extracts can affect immune cells and mitochondrial function, but acute crossover human evidence is limited and this specific product combination is relatively untested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy adults; * Age 18 - 75 years (inclusive); * BMI between 18.0 and 34.9 (inclusive); * Veins easy to see in one or both arms (to allow for the multiple blood draws); * Willing to comply with study procedures, including: * Maintaining a consistent diet and lifestyle routine throughout the study, * Consistent habit of bland breakfasts on days of clinic visits, * Abstaining from exercising and nutritional supplements on the morning of a study visit, * Abstaining from use of coffee, tea, and soft drinks for at least one hour prior to a clinic visit; * Abstaining from music, candy, gum, computer/cell phone use (airplane mode is allowed), during clinic visits. Exclusion Criteria: * Previous major gastrointestinal surgery (absorption of test product may be altered) (minor surgery not a problem, including previous removal of appendix and gall bladder); * Taking anti-inflammatory medications on a daily basis; * Currently experiencing intense stressful events/ life changes; * Currently in intensive athletic training (such as marathon runners); * Currently taking antipsychotic medications such as clozapine, Risperdal, Abilify, Zyprexa or Seroquel; * An unusual sleep routine (examples: working graveyard shift, irregular routine with frequent late nights, studying, partying); * Unwilling to maintain a constant intake of supplements over the duration of the study; * Anxiety about having blood drawn; * Pregnant, nursing, or trying to become pregnant; * Known food allergies related to ingredients in active test product or placebo.
Where it's running
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NIS Labs
Klamath Falls, Oregon, United States Recruiting
Study contacts
- Study coordinator: Gitte S. Jensen, PhD
- Email: Gitte@nislabs.com
- Phone: 5418820112
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.