Rapid effects of a biofield skin patch on antioxidant levels and cellular energy

Rapid Effects of a Biofield Patch on Antioxidant Status and Cellular Energy

This trial tests whether wearing an active biofield skin patch versus a placebo patch produces rapid changes in antioxidant enzymes, glutathione, mitochondrial function, and inflammatory markers in healthy adults.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 12 (estimated)
• Ages: 18 Years to 75 Years
• Sex: All
• Sponsor: Natural Immune Systems Inc (Academic / other)
• Drugs / interventions: Chemotherapy
• Locations: 1 site (Klamath Falls, Oregon)
• Trial ID: NCT07314359 on ClinicalTrials.gov

What this trial studies

This is a randomized, double-blind, placebo-controlled crossover proof-of-concept study with an additional open-label week where participants wear the active patch daily before the final visit. Multiple blood samples will be taken to measure endogenous antioxidant protection (superoxide dismutase and glutathione), mitochondrial energy production and biogenesis in white blood cells under normal and ex vivo-stressed conditions, and cytokine levels in serum and serum-derived extracellular vesicles. The primary comparison is between the active non-transdermal photobiomodulating patch and a matched placebo patch to document acute biomarker changes. Participants are healthy adults who must follow pre-visit restrictions and have veins accessible for multiple draws.

Who should consider this trial

Good fit: Ideal candidates are healthy adults aged 18–75 with BMI 18.0–34.9 who have visible veins for multiple blood draws and can follow the study's dietary and activity restrictions.

Not a fit: People with recent cancer or chemotherapy, those taking prescription weight-loss or cholesterol-lowering medications, or those with acute serious illness are unlikely to qualify or benefit from this protocol.

Why it matters

Potential benefit: If successful, the patch could offer a noninvasive way to quickly enhance antioxidant defenses and mitochondrial resilience, potentially supporting recovery from oxidative stress.

How similar studies have performed: The non-transdermal biofield patch approach is largely novel with limited direct clinical evidence, although related photobiomodulation and antioxidant biomarker studies have reported mixed and preliminary findings.

Eligibility criteria

Inclusion Criteria:

* Healthy adults;
* Age 18 - 75 years (inclusive);
* BMI between 18.0 and 34.9 (inclusive);
* Veins easy to see in one or both arms (to allow for the multiple blood draws);
* Willing to comply with study procedures, including:

  * Maintaining a consistent diet and lifestyle routine throughout the study,
  * Consistent habit of bland breakfasts on days of clinic visits,
  * Abstaining from exercising and nutritional supplements on the morning of a study visit,
  * Abstaining from use of coffee, tea, and soft drinks for at least one hour prior to a clinic visit;
  * Abstaining from music, candy, gum, computer/cell phone use (airplane mode is allowed), during clinic visits.

Exclusion Criteria:

* Cancer during past 12 months;
* Chemotherapy during past 12 months;
* Currently taking prescription weight loss drugs (such as semaglutide);
* Currently taking cholesterol-lowering medication (for example: statins);
* Currently experiencing intense stressful events/life changes;
* Currently in intensive athletic training (such as marathon runners);
* Currently taking anxiolytic, hypnotic, or anti-depressant prescription medication;
* Immunization during past 6 months;
* An unusual sleep routine (examples: working graveyard shift, irregular routine with frequent late nights, studying, partying);
* Unwilling to maintain a constant intake of supplements over the duration of the study;
* Anxiety about having blood drawn;
* Pregnant, nursing, or trying to become pregnant;
* Known allergies related to adhesive materials.

Where this trial is running

Klamath Falls, Oregon

• NIS Labs — Klamath Falls, Oregon, United States (Recruiting)

Study contacts

• Study coordinator: Giite S Jensen, PhD

Conditions Antioxidant Status; Superoxide dismutase activity; Glutathione; Mitochondria; Cytokines