Rapid assessment of infectious keratitis using cytokines and imaging

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to develop a non-invasive, rapid diagnostic approach for infectious keratitis by evaluating the influence of TNF-alpha on bacterial pathogens and creating an algorithm to distinguish between different types of keratitis-causing pathogens. It utilizes optical coherence tomography (OCT) and tear cytokine analysis to improve diagnostic accuracy and speed compared to traditional methods. The study addresses the limitations of conventional corneal scraping and bacterial culturing, which can be invasive and time-consuming. By analyzing tear samples, the research seeks to enhance understanding of keratitis and facilitate quicker, targeted treatment options.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Men and women age of at least 18 years to 119 years
* Written informed consent prior to study-related procedures
* First presentation with keratitis (corneal epithelial ulceration, corneal edema and/or stromal infiltration with inflammatory cells) within 10 days.
* Untreated keratitis or keratitis not responding to the given treatment

Exclusion Criteria:

Subjects will be excluded if one or more of the following criteria apply:

* Symptoms for more than 10 days
* Presence or history of a severe medical condition as judged by the clinical investigator
* Pregnancy, planned pregnancy or lactating

Where it's running

• Kepler University Hospital
  Linz, Upper Austria, Austria Recruiting

Study contacts

• Principal investigator: Matthias Bolz, MD — JKU Linz
• Study coordinator: Nino D Hirnschall, MD,PhD
• Email: nino.hirnschall@kepleruniklinikum.at
• Phone: 004373278061510

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.