Radiation segmentectomy with Y-90 resin microspheres for liver tumors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a multicenter prospective observational registry of adults with hepatocellular carcinoma or liver metastases treated with selective Y-90 resin microsphere infusion to the tumor-bearing hepatic segment. Teams will record administered dose, liver function, imaging responses, and adverse events at scheduled follow-up visits to determine safety and to describe dose thresholds linked to complete radiologic response. The main analysis will relate segmental radiation dose to rates of complete response, local control, and treatment-related toxicity. Data from participating centers in Adana, Turkey will be pooled to produce practical dose recommendations for resin microsphere segmentectomy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged ≥18 years
* Underwent RE as a RS intent (have single or \<3 tumors in same or neighboring 2 segments) for the treatment of HCC or metastatic tumor to liver.
* Presence of extrahepatic disease
* Tumor size less than 8 cm
* Child Pugh Score \<B9

Exclusion Criteria:

* Presence of macrovascular invasion,
* Presence of extrahepatic disease,
* Cholangiocarcinoma or mixed HCC-cholangiocarcinoma
* Not willing to attend follow-up visits.

Where it's running

• Acibadem Adana Hospital
  Adana, Turkey (Türkiye) Recruiting
• Hacettepe University
  Ankara, Turkey (Türkiye) Recruiting
• Cam ve Sakura Education and Reseach Hospital
  Istanbul, Turkey (Türkiye) Recruiting
• Istanbul University Capa Medical School
  Istanbul, Turkey (Türkiye) Recruiting
• Marmara University
  Istanbul, Turkey (Türkiye) Recruiting
• Katip Celebi Education and Research Hospital
  Izmir, Turkey (Türkiye) Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Next Generation Delivery System (NGDS) for SBRT in thorax and upper abdomen

  A study tests a new machine to deliver SBRT more quickly and comfortably for adults with thoracic or upper abdominal cancers.

  Recruiting at 2 sites Varian, a Siemens Healthineers Company · St Louis, Missouri and 1 other locations · NCT07824583

• Personalized exercise plan for cancer survivors

  This study tests a personalized, physician-guided exercise program for adults who have completed cancer treatment, to see if a safe, structured plan can be implemented in routine care.

  Recruiting Kaohsiung Medical University Chung-Ho Memorial Hospital · Kaohsiung, Taiwan · NCT07751783

• Personalized computer-guided planning for radioembolization in liver cancer

  This project will try using patient-specific computer models of liver blood flow to predict where radioactive microspheres go during transarterial radioembolization for people with hepatocellular carcinoma.

  Recruiting University Hospital, Ghent · Ghent · NCT07315633

• Adding angiotensin II to liver radioembolization to boost tumor radiation

  This trial will test whether a short intra-arterial infusion of angiotensin II given just before yttrium-90 radioembolization helps more radiation reach liver tumors and less reach healthy liver in adults with advanced or metastatic liver cancer.

  Recruiting Phase 2 UMC Utrecht · Utrecht, Utrecht · NCT07312292

• NIR‑II fluorescence guidance with ICG‑cisplatin nanoprobes for liver tumor resection

  This study tries a new ICG‑cisplatin nanoprobe injected through the liver artery to help surgeons see and remove single small hepatocellular carcinomas during laparoscopic anatomic hepatectomy.

  Recruiting Early Phase 1 West China Hospital · Chengdu, Sichuan · NCT07295262

• Digital early-warning system to predict acute lung injury after major liver surgery

  This study will try a machine-learning based warning tool to predict early acute lung injury in adults having major liver surgery.

  Recruiting at 4 sites Beijing Tsinghua Chang Gung Hospital · Beijing, Beijing Municipality and 3 other locations · NCT07070362

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.