Radial artery versus no-touch saphenous vein grafts for women having coronary bypass

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, unblinded, randomized single-center trial enrolling 110 women with left main and/or multivessel coronary disease who require CABG. Participants are randomized 1:1 to receive either a radial artery graft to the lateral wall or no-touch saphenous vein grafts for non-LAD targets, with the internal thoracic artery used to graft the LAD in all patients. The primary outcome is the proportion of functioning versus occluded radial and no-touch vein grafts at one year; secondary outcomes include MACCE at 30 days and 12 months, perioperative complications, and angina class at one year. Additional grafts may be saphenous veins or other arterial conduits at the surgeon's discretion.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Three-vessel disease involving the target circumflex artery with stenosis ≥70% and a diameter ≥1.5 mm
2. Females aged 18 years and older
3. Signed informed consent
4. Clinical indications for coronary revascularization (refractory angina/transient myocardial ischemia according to noninvasive tests)

Exclusion Criteria:

1. Previous cardiac surgery of any type, including CABG
2. Combined procedures
3. Ineligibility for venous or radial artery harvesting as determined by preoperative Doppler flowmetry or clinical examination that would compromise graft patency.
4. Acute myocardial ischemia
5. EF less than 35%
6. CKD 4.5
7. Inability to understand the nature, scope, and consequences of the clinical trial, or to provide written informed consent due to cognitive impairment or mental illness.
8. Life expectancy less than 1 year due to non-cardiac diseases.

Where it's running

• Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia
  Tomsk, Russia Recruiting

Study contacts

• Principal investigator: Yuri Y. Veshersky, MD, PhD — Cardiology Research Institute, Tomsk National Research Medical Center
• Study coordinator: Vasily V. Zatolokin, PhD
• Email: zatolokin@cardio-tomsk.ru
• Phone: +79138490545

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Drug-coated balloon treatment versus medication for fat-rich coronary plaques

  This trial will test whether using a paclitaxel-coated balloon during PCI can reduce the fat content of dangerous coronary plaques in adults with acute coronary syndrome compared with standard medication alone.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam · NCT07107971

• REASSURE-NIRS registry of lipid-rich plaque in coronary arteries

  This registry will use near-infrared spectroscopy during angiography to see how lipid-rich plaque in people with coronary artery disease relates to risk factors, medications, procedures, and outcomes.

  Recruiting at 2 sites National Cerebral and Cardiovascular Center, Japan · Miyazaki and 1 other locations · NCT04864171

• Ziltivekimab to reduce coronary plaque after a heart attack

  This study will test whether the anti-inflammatory drug ziltivekimab can reduce plaque buildup and improve plaque composition in people who recently had a heart attack and were treated with PCI.

  Recruiting Phase 3 ECRI bv · Bern · NCT07276282

• Comparing PET/CT and Cardiac CT for Detecting Heart Disease

  This study is testing if a new type of imaging called NaF-PET/CT can find heart disease better than the standard cardiac CT in patients showing symptoms of coronary artery disease.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT05994014

• How coronary artery shape affects plaque and blood flow

  This project tests whether combining coronary CT scans with computer simulations of blood flow can help identify high-risk plaques in adults aged 40–70 who have symptoms or risk factors for coronary artery disease.

  Recruiting Bangladesh University of Engineering and Technology · Dhaka · NCT07002697

• Using cold therapy inside coronary arteries to stabilize high‑risk plaque in people with angina or recent heart attack

  This trial will try a device that delivers cold inside a coronary artery to see if it reduces dangerous plaque in people with symptomatic coronary artery disease (stable angina or recent acute coronary syndrome).

  Recruiting Cryotherapeutics SA · Aalst and 2 other locations · NCT06939374

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.