Quantum Molecular Resonance to Treat Neuropathic Corneal Pain and Regrow Corneal Nerves

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with neuropathic corneal pain will attend nine visits including one baseline assessment and eight QMR treatment sessions using a Rexon-Eye device. At each visit participants will undergo ocular surface exams, in vivo confocal microscopy to measure corneal nerve morphology, tear protein collection, and symptom and quality-of-life questionnaires. Investigators will compare pain scores, corneal nerve metrics, ocular surface findings, and tear biomarkers before and after the QMR treatment course. The study team hypothesizes that repeated QMR sessions will reduce pain, stimulate corneal nerve regeneration, and improve patient-reported quality of life.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Be at least 21 years of age.
* Regardless of gender (Male/Female).
* Regardless of race (Chinese/Malay/Indian/Eurasian/Others).
* Diagnosed with neuropathic corneal pain based on the following criteria: presence of neuropathic ocular symptoms (burning, stinging, photophobia, pain, severe dryness), absent or minimal slit-lamp findings to explain the symptoms and corneal nerve abnormalities as detected by IVCM (decreased corneal length and density, presence of neuromas).
* Willing to receive all eye examinations in this study.

Exclusion Criteria:

* Pregnant women.
* Participants carrying active implantable devices (e.g., pacemakers and hearing aids).
* Oncologic patients under treatment; patient who underwent ocular surgery in the last month.
* Participants who had ocular infection within 6 months, or active ocular infection or inflammation; any concomitant ocular diseases that could potentially induce ocular pain, such as uveitis.

Where it's running

• Singapore National Eye Centre
  Singapore, Singapore Recruiting

Study contacts

• Study coordinator: Yu-Chi Liu, MD, MCI, PhD
• Email: liu.yu.chi@snec.com.sg
• Phone: 65 65767287

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.