Purine-rich diet for patients with AICA-ribosiduria
Official title: PURICA : Purine Supplementation in Patients With AICA-Ribosiduria
Run by Centre Hospitalier Universitaire de Saint Etienne · NCT06845501 · Data updated 2026-11-12
This study is testing whether a purine-rich diet can help people with AICA-ribosiduria feel better by reducing their symptoms.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 3 Years and up |
| Sex | All |
| Enrollment | 10 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Saint Etienne Academic / other |
| Locations | 1 site (Saint-Etienne) |
| Status | Recruiting |
| Started | April 24, 2025 |
| Main results expected | March 2027 |
| Study ends | May 2029 |
| Registry record updated | May 8, 2026 |
| Trial ID | NCT06845501 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals diagnosed with AICA-ribosiduria due to ATIC deficiency.
✕Probably not a fit
Patients who are already on a purine-rich diet may not benefit from this study due to theoretical contraindications.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effects of a purine-rich diet on patients suffering from AICA-ribosiduria due to ATIC deficiency, a rare genetic metabolic disorder. The research aims to replicate previous findings that suggested a decrease in disease biomarkers after dietary intervention. By enrolling multiple patients, the study seeks to evaluate the potential benefits of this dietary approach in managing severe symptoms associated with the condition. The study is designed to provide insights into the efficacy of dietary changes in treating this orphan disease.
Why it matters
Potential benefit: If successful, this approach could significantly improve the quality of life for patients with AICA-ribosiduria by alleviating severe symptoms and potentially reducing disease biomarkers.
How similar studies have gone: Previous studies have shown promising results with dietary interventions in similar conditions, suggesting potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Individual affected by AICA-ribosiduria due to ATIC deficiency Exclusion Criteria: \- Individual already on a purine-rich diet theoretical contraindication to a purine-rich diet
Where it's running
-
Chu Saint-Etienne
Saint-Etienne, France Recruiting
Study contacts
- Principal investigator: Francis RAMOND, doctor of medicine — Centre Hospitalier Universitaire de Saint Etienne
- Study coordinator: Francis RAMOND, doctor of medicine
- Email: Francis.Ramond@chu-st-etienne.fr
- Phone: 0477828798
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.