Pulpotomy versus partial pulpectomy for deep cavities in primary molars
Official title: Clinical and Radiographic Success Rate of Pulpotomy Versus Pulpectomy for Management of Primary Teeth With Deep Caries: A Randomized Clinical Trial
Run by Cairo University · NCT06293521 · Data updated 2026-11-12
This trial tests whether pulpotomy or partial pulpectomy better treats vital primary molars with deep cavities and irreversible pulpitis in children aged 4 to 6.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Ages | 4 Years to 6 Years |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Cairo) |
| Status | Recruiting |
| Started | December 1, 2026 |
| Main results expected | January 31, 2027 |
| Study ends | April 1, 2027 |
| Registry record updated | September 23, 2026 |
| Trial ID | NCT06293521 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are healthy children aged 4–6 with restorable vital primary molars showing deep caries, pulp exposure, and continued bleeding after coronal pulp removal.
✕Probably not a fit
Children with swelling, pathological mobility, preoperative radiographic pathology (resorption or periradicular/furcation radiolucency), previously accessed teeth, or those unable to attend follow-up visits are unlikely to benefit from this trial.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This Phase 2 interventional trial compares clinical and radiographic success rates of pulpotomy (using calcium silicate–based materials) versus partial pulpectomy for vital primary molars with deep caries and signs of irreversible pulpitis. Children aged 4–6 in good general health with restorable, exposed primary molars and prolonged bleeding after coronal pulp removal will be enrolled and treated at Cairo University. Participants will receive one of the two procedures and be followed with clinical exams and dental radiographs at scheduled visits to monitor pain, infection signs, and radiographic healing. Teeth with preoperative radiographic pathology, swelling, or pathological mobility are excluded and outcomes will be compared to determine which approach best preserves tooth function and structure.
Why it matters
Potential benefit: If successful, the less invasive pulpotomy approach could preserve more primary teeth with fewer procedures and complications than pulpectomy.
How similar studies have gone: While calcium silicate–based pulpotomy techniques have shown success in mature permanent teeth and some emerging pediatric reports, high-quality evidence specifically in primary teeth with irreversible pulpitis remains limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Aged 4 to 6 years , in good general health 2. The parents provided written informed consent. 3. Clinical characteristics, defined as spontaneous pain and the presence of a deep carious lesion with pulp exposure and bleeding that did not halt within five minutes following removal of the coronal pulp tissue. 4. Restorable teeth. Exclusion Criteria: 1. Physical or mental disability. 2. Unable to attend follow-up visits. 3. Previously accessed teeth. 4. Swelling, tenderness to percussion or palpation, or pathological mobility. 5. Pre-operative radiographic pathology such as resorption (internal or external), per-radicular or furcation radiolucency.
Where it's running
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Cairo University
Cairo, Egypt Recruiting
Study contacts
- Study coordinator: Nada Mostafa, B.D.S
- Email: Nadamostafa@dentistry.cu.edu.eg
- Phone: 01117311533
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Direct pulp capping for deep and extremely deep caries in mature molars with reversible pulpitis
This study tests whether direct pulp capping works similarly for deep versus extremely deep caries in adult, mature mandibular molars with reversible pulpitis.
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Egyptian MTA and Biodentine versus Calcium Hydroxide for indirect pulp capping in permanent teeth
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Impact of Symptoms and Lesion Depth on Partial Carious Tissue Removal
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.