PUFFINS Brain Health Imaging

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

PUFFINS compares novel low-field, ultra-low-field, and field-cycling MRI methods with conventional 3T MRI in people with cerebral small vessel disease. Eligible participants will undergo enrollment and follow-up research scans using each imaging approach at University of Aberdeen imaging sites to compare image quality and detection of SVD features. The goal is to see whether lower-cost, simpler scanners can reliably identify markers of SVD and track changes over time. Results will guide development of more accessible MRI options for diagnosis and monitoring of small vessel disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults ≥ 50 years old.
* Subjects who do not report problems with memory.
* Small vessel disease (Fazekas score 1 to 3).
* Suitable body habitus.
* Able to understand written and spoken English.

Exclusion Criteria:

* History of major stroke (minor stroke/Transient Ischaemic Attacks or lacunar stroke are acceptable).
* Individuals unable to give informed consent.
* Contra-indications to MRI scanning such as implantable cardiac devices.

Where it's running

• Aberdeen Biomedical Imaging Centre, University of Aberdeen
  Aberdeen, United Kingdom Recruiting
• AMT Center, Univeristy of Aberdeen
  Aberdeen, United Kingdom Recruiting

Study contacts

• Study coordinator: Mary Joan MacLeod
• Email: m.j.macleod@abdn.ac.uk
• Phone: +44 1224 438352

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Cerebral Small Vessel Disease Progression by Stroke Type

  This study tests whether CSVD progresses differently if a patient has a concurrent ischemic stroke, using MRI and blood biomarkers in adults.

  Recruiting University Hospital Ulm · Ulm, Baden-Wurttemberg · NCT07611136

• Brain activity and thinking problems in cerebral small vessel disease

  This project will see if EEG brain signals and home-based cognitive training or tACS can detect and improve thinking problems in older adults with cerebral small vessel disease.

  Recruiting University Hospital, Bordeaux · Bordeaux · NCT07068620

• Edaravone Dexborneol sublingual tablets for acute small-vessel ischemic stroke

  This trial will test whether taking Edaravone Dexborneol sublingual tablets twice daily helps adults aged 30–80 who recently had a small subcortical ischemic stroke.

  Recruiting Phase 3 Peking Union Medical College Hospital · Beijing · NCT06674460

• Improving brain blood flow in patients with cerebral small vessel disease

  This study is testing if a new drug can improve blood flow in the brains of people with cerebral small vessel disease.

  Recruiting Imperial College London · London · NCT06643013

• Exploring the link between deep medullary veins and cognitive issues in small vessel disease

  This study is trying to see if changes in certain brain veins are linked to thinking problems in people with small vessel disease.

  Recruiting Zigong No.1 Peoples Hospital · Zigong, Sichuan · NCT05715710

• Using GLP-1 analogue to prevent progression of small vessel disease

  This study is testing if a new medication can help people with moderate-to-severe small vessel disease in the brain slow down its progression compared to standard treatment alone.

  Recruiting at 2 sites Phase 2 Chinese University of Hong Kong · Wenzhou, Zhejiang and 1 other locations · NCT05356104

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.