Pseudo-CT MRI sequences to detect bone lesions in multiple myeloma
Official title: Evaluation of Optimised Whole-body MRI Examinations Incorporating "Pseudo-scanner" Sequences (ZTE, "Zero Echo Time" AND Lava Flex) for the Detection of Bone Lesions in Multiple Myeloma
Run by Cliniques universitaires Saint-Luc- Université Catholique de Louvain · NCT06988020 · Data updated 2026-11-12
This tests whether new 'pseudo-CT' MRI sequences can detect bone lesions during a single whole-body MRI in people with newly diagnosed multiple myeloma.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 45 (estimated) |
| Sponsor | Cliniques universitaires Saint-Luc- Université Catholique de Louvain Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Brussels) |
| Status | Recruiting |
| Started | April 22, 2025 |
| Main results expected | November 2027 |
| Study ends | November 2027 |
| Registry record updated | April 24, 2026 |
| Trial ID | NCT06988020 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults with newly diagnosed multiple myeloma who need baseline bone staging, can safely undergo MRI (no incompatible implants, not pregnant), and are not already designated to have PET/CT as the preferred imaging.
✕Probably not a fit
Patients with MRI-incompatible implants, severe claustrophobia, pregnancy, those with recurrent disease after intensive treatment, or those for whom PET/CT is the indicated imaging will likely not benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The protocol adds Zero Echo Time and Lava Flex Low Flip Angle "pseudo-CT" sequences into whole-body MRI to visualize mineral bone in addition to marrow. These sequences incorporate deep-learning denoising and chemical-shift correction to reduce noise and artifact and improve visualization of osteolysis. Newly diagnosed multiple myeloma patients requiring staging will undergo whole-body MRI with the pseudo-CT sequences and imaging results will be compared to standard imaging and clinical reference standards. The aim is to determine whether a single, non‑irradiating MRI exam can reliably show both marrow involvement and osteolytic lesions.
Why it matters
Potential benefit: If successful, this could allow patients to have one radiation-free whole-body MRI that shows both marrow disease and bone loss, simplifying staging and reducing CT/PET-CT exposure.
How similar studies have gone: Early pilot work has shown promising diagnostic performance for pseudo-CT sequences in detecting osteolytic lesions, but whole-body MRI integration with deep-learning corrections is still relatively new and not yet widely validated.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Patient with newly diagnosed multiple myeloma, for whom bone imaging is required for staging. * Recurrent patient after intensive treatment (high dose chemotherapy, bone marrow transplant, etc.). * Patient requiring a PET / CT considered as the technique of choice in these stages of the disease. Exclusion Criteria: * Implanted material incompatible with MRI. * Severe claustrophobia. * Pregnant women
Where it's running
-
Cliniques universitaires Saint-Luc
Brussels, Belgium Recruiting
Study contacts
- Principal investigator: Frédéric Lecouvet — Cliniques universitaires Saint-Luc- Université Catholique de Louvain
- Study coordinator: Frédéric Lecouvet
- Email: frederic.lecouvet@saintluc.uclouvain.be
- Phone: +3227642793
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Biomarker study to predict Vagus Nerve Stimulation response in adults with refractory epilepsy
This study tests whether biomarkers and network measures can predict how adults with refractory epilepsy will respond to vagus nerve stimulation (VNS) after implantation.
-
How SpO₂ Changes During Reoxygenation After Breath-Holds
This study tests how peripheral oxygen saturation readings from pulse oximeters behave during deliberate breath-holds and rapid reoxygenation in healthy adults.
-
Zero Echo Time MRI with pseudo-CT for lumbar spine bone problems
This study tests MRI using pseudo-CT sequences (ZTE/UTE) to see if it can match or improve over CT for people with lumbar spine bone issues who would normally get a CT scan.
-
Myokines in metabolic and endocrine diseases linked to sarcopenia
This study tests whether myokines can serve as biomarkers or drivers of sarcopenia and sarcopenic obesity in people with metabolic or endocrine diseases.
-
Transcutaneous Electrical Nerve Stimulation for Acute Low Back Pain in EDs
This trial tests whether TENS can relieve acute low back pain in adults who come to the emergency department.
-
Propofol versus sevoflurane effects on frontal EEG alpha power during anesthesia
This trial will test whether propofol or sevoflurane produces different frontal EEG alpha power in adults having elective electrophysiology procedures under general anesthesia.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.