PRP injections versus hyaluronic acid for advanced knee osteoarthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will run a randomized, open-label study comparing intra-articular PRP injections to hyaluronic acid (HA) injections in patients with MRI-confirmed grade III-IV knee osteoarthritis at Hôpital Sainte Musse in Toulon. Participants will be followed for 12 months after their last injection and outcomes will include pain (VAS), function (WOMAC), and quality of life (EQ-5D-5L). The trial uses standard-of-care injection procedures and validated questionnaires to measure changes over time. The aim is to determine which injection better reduces the functional impact of advanced gonarthrosis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥ 18 years ;
2. MRI confirmed grade III or IV unilateral gonarthrosis ;
3. Pain ≥ 3/10 on the visual analogue scale (VAS);
4. Patient with a BMI \< 35
5. Patient capable of giving consent prior to participation in the study;
6. Affiliated or entitled under a social security scheme.

Exclusion Criteria:

1. Non-steroidal anti-inflammatory drugs\* or corticosteroids\*\* taken in the 7 days prior to inclusion;
2. Local injection of hyaluronic acid in the 2 months prior to inclusion;
3. Local injection of PRP within 1 year prior to inclusion;
4. Local injection of corticosteroids within 5 months prior to inclusion;
5. Current anticoagulant treatment that cannot be stopped during the hyaluronic acid or PRP injection protocol period;
6. Patient diagnosed with any type of cancer in the last 3 years;
7. Pregnant women, women in labour or breast-feeding women;
8. Patients under judicial protection (guardianship, curatorship, etc.) or safeguard of justice;
9. Any other reason which, in the opinion of the investigator, could interfere with the evaluation of the study objectives.

   * Acetylsalicylic acid is allowed when it is prescribed as an antiplatelet agent at doses lower than or equal to 160 mg per day. It has, indeed, no anti-inflammatory effect at these doses.

     * Corticosteroids can be administered when they have a local action different from the one applied to the treated knee (cutaneous, instiled or inhaled routes).

Where it's running

• Centre Hospitalier Intercommunal de Toulon- La Seyne sur Mer - Hôpital Sainte Musse
  Toulon, Var, France Recruiting

Study contacts

• Study coordinator: Sophie Lafond
• Email: sophie.lafond@ch-toulon.fr
• Phone: 0483772062

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.