PRP Injection for Thumb Base Osteoarthritis (CMC-I) to See if It Reduces Pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This Phase 2 trial compares a single ultrasound-guided platelet-rich plasma injection with a saline placebo in adults with thumb base (CMC-I) osteoarthritis. Participants will be followed for 12 months with visits at 3, 6, 9, and 12 months to assess pain, hand function, grip and pinch strength, thumb motion, and joint characteristics on ultrasound. The study aims to determine whether PRP can reduce pain and improve hand function compared to placebo and to monitor any adverse events. Eligible participants have non-severe CMC-I OA and have not responded to initial conservative therapy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 or older
* Patients with an Eaton-littler score of I, II or III
* Patients with uni- or bilateral CMC-I osteoarthritis
* Non-responders to conservative therapy i.e., hand therapy and immobilisation after 3 months

Exclusion Criteria:

* Aged below 18
* Patients with an Eaton-littler score of IV (STT arthrosis)
* Surgical interventions of the CMC-I joint
* A known articular systemic disease (e.g. rheumatoid arthritis) or additional hand osteoarthritis/ tenosynovitis or metabolic disease like diabetes mellitus
* Patients with an infectious arthritis of CMC-I joint
* A known psychiatric condition
* Neuropathic chronic pain syndrome
* Intra articular injection 6 months prior to inclusion
* Smoking
* Active use of statins

Where it's running

• GOED Medisch Centrum
  Breda, North Brabant, Netherlands Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.