Protocol to enhance acceptance of intestinal transplants
A Multifactorial Immunomodulatory Protocol -Promoting T-regulatory Cells- Prolongs Graft and Patient Survival After Intestinal Transplantation
This study tests a new approach to help people who receive intestinal transplants accept their new organs better and improve their overall outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 13 (estimated) |
| Sex | All |
| Sponsor | Universitaire Ziekenhuizen KU Leuven Academic / other |
| Locations | 1 site (Leuven) |
| Trial ID | NCT02314949 on ClinicalTrials.gov |
What this trial studies
This observational study applies a tolerogenic protocol designed to promote T-regulatory cells in intestinal transplant recipients. The approach involves a four-step process that includes donor-specific blood transfusion, minimizing steroid use, reducing calcineurin inhibitors, and maintaining mucosal integrity. The protocol has been in use since 2000 and is based on preclinical research conducted by the investigators. The aim is to create a favorable environment for graft acceptance and improve transplant outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are patients awaiting intestinal transplantation.
Not a fit: Patients who are receiving living donations will not benefit from this study.
Why it matters
Potential benefit: If successful, this protocol could lead to improved acceptance of intestinal transplants and better long-term outcomes for patients.
How similar studies have performed: Other studies have shown promise in using immunomodulatory approaches for organ transplantation, making this protocol a potentially valuable addition to existing methods.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * all patients awaiting intestinal transplantation Exclusion Criteria: * living donation
Where this trial is running
Leuven
- UZ Leuven — Leuven, Belgium (Recruiting)
Study contacts
- Study coordinator: Jacques Pirenne, MD,PhD,MsC
- Email: jacques.pirenne@uzleuven.be
- Phone: +32 16 34 87 27
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.