Prospective multicenter observational registry for chronic kidney disease in China

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Approximately 3,000 adults with chronic kidney disease will be enrolled from around 80 hospitals selected across different regions of China to create a nationally representative cohort. The registry is observational and non-interventional; participants will be followed for up to 96 weeks with data extracted from medical records and entered into a cloud-based electronic case report form using an EDC system. Participating sites include a mix of tertiary academic centers, regional medical centers, and representative secondary hospitals to reflect real-world practice at multiple levels of care. Investigators will obtain written informed consent and assign a unique subject identifier before enrollment, and inclusion/exclusion criteria (e.g., excluding ESRD on RRT, recent AKI, pregnancy, or life expectancy <2 years) will be applied.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male or female patients aged ≥18 years.
* Willing and able to provide written informed consent to participate in the study.
* Confirmed CKD diagnosis at enrolment, defined by at least one of the following:

  * eGFR \<60 mL/min/1.73 m² for ≥3 months, OR
  * Evidence of kidney damage (e.g., UACR ≥30 mg/g or UPCR ≥150 mg/g, structural abnormality on imaging, or kidney biopsy findings consistent with chronic kidney injury) persisting for ≥3 months

Exclusion Criteria:

* Having a life-threatening comorbidity with life expectancy \< 2 years.
* Severe cardiac disease: life-threatening arrhythmias, or recent MACE (Myocardial infarction (MI), stroke, CV death) within the past 3 months.
* Pregnant or breastfeeding women.
* Currently enrolled in any interventional clinical trial or receiving investigational therapy within 3 months of enrollment.
* Presenting with ESRD, RRT, acute kidney injury (AKI), acute kidney disease (i.e., kidney injury or a decline in renal function persisting for ≤3 months) as a primary disease condition at enrollment.

Where it's running

• Research Site
  Anning, Yunnan - South Region, China Recruiting
• Research Site
  Beijing, Beijing, China Recruiting
• Research Site
  Cangzhou, Hebei - North Region, China Recruiting
• Research Site
  Caoxian County, Shandong Province, China Recruiting
• Research Site
  Changzhou, Jiangsu Province, China Recruiting
• Research Site
  Chengdu, Sichuan Province, China Recruiting

+9 more sites. See ClinicalTrials.gov for the full list.

Study contacts

• Principal investigator: Xiao Qiang Ding — Zhongshan Hospital Affiliated with Fudan University
• Study coordinator: AstraZeneca Clinical Study Information Center
• Email: information.center@astrazeneca.com
• Phone: 1-877-240-9479

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.