Propofol titration to improve blood pressure stability during anaesthesia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Propofol commonly causes drops in blood pressure after anaesthesia induction, which can harm organs in older or multimorbid patients. This multicentre, single-blinded, expertise-based randomized trial compares a slow, need-based titration using propofol target-controlled infusion (Schnider model) with conventional induction dosing (with remifentanil TCI using the Minto model) in patients aged 55 and older undergoing planned non-cardiac surgery. The primary focus is on blood pressure stability and post-induction hypotension, with secondary analyses of clinical applicability and potential economic impact. Participating centres are in Switzerland and the trial uses standard perioperative monitoring and protocols across sites.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults ≥ 55 years old
* Patients undergoing any of the following planned surgery under general anaesthesia with intubation: Ear, nose and throat, gynaecological, maxillofacial, orthopedic, plastic and reconstructive, spine, urologic, vascular (varicose vein surgery, femoral endarterectomy, peripheral bypass surgery) and visceral surgery
* Standard procedure for anaesthesia with propofol Target-Controlled Infusion (TCI) using the Schnider model and remifentanil TCI using the Minto model
* American Society of Anesthesiologists Physical Status Classification system (ASA PS) I-IV
* Body mass index (BMI) ≥18.5 or \<35 kg/m2
* Signed written informed consent

Exclusion Criteria:

* Special forms of anaesthesia induction, specifically awake tracheal intubation and rapid sequence induction
* Combined anaesthesia procedures (general and regional anaesthesia combined)
* Special forms of general anaesthesia (opioid-free anaesthesia or any opioid-sparring modifications with lidocaine, magnesium, ketamine, clonidine or dexmedetomidine)
* Surgery in the prone position within the first 30 minutes
* Patients with known difficult airway
* Daily consumption of alcohol (\> one unit/day) or \> seven units/week
* Any regular recreational drug abuse
* Chronic use of benzodiazepines or opioids
* Allergy to propofol
* Patients with known brain pathologies, specifically seizure disorders, stroke within the past 9 months or dementia
* History of awareness
* Inability to follow procedures or insufficient knowledge in German

Where it's running

• University Hospital Basel
  Basel, Switzerland Recruiting
• Kantonsspital Baden
  Baden, Switzerland Not yet recruiting
• Cantonal Hospital Graubünden
  Chur, Switzerland Not yet recruiting
• Kantonsspital Olten, soH
  Olten, Switzerland Not yet recruiting

Study contacts

• Principal investigator: Salome Dell-Kuster, Prof. Dr. med — University Hospital, Basel, Switzerland
• Study coordinator: Martin Lohri, Dr. med.
• Email: martindominik.lohri@usb.ch
• Phone: +41 61 556 52 27

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Predicting bowel leaks after colorectal surgery with a computer model and surgeon input

  This study tests a computer model that predicts anastomotic leaks after colorectal surgery, and sees if adding surgeons’ intuition improves the predictions.

  Recruiting at 2 sites University Hospital, Basel, Switzerland · Liestal, Basel-Landschaft and 1 other locations · NCT07888478

• Active surveillance after immunotherapy for MMR-deficient colorectal and GI cancers

  This study looks at whether some patients with non-metastatic, MMR-deficient or MSI-H colorectal cancers can skip surgery after a strong response to immunotherapy.

  Recruiting at 3 sites University Hospital, Basel, Switzerland · Basel and 2 other locations · NCT07829081

• PCI Registry at University Hospital Basel for Complex Coronary Procedures

  This registry collects real-world data from adults undergoing percutaneous coronary interventions at University Hospital Basel to see how different treatments like drug-eluting stents, drug-coated balloons, and bioresorbable scaffolds perform in diverse patients.

  Recruiting University Hospital, Basel, Switzerland · Basel, Canton of Basel-City · NCT07814157

• Severe Complications During VT/PVC Ablation

  This study looks at real-world cases to see what severe complications occur during VT or PVC ablations and how patients are managed afterward.

  Recruiting at 25 sites University Hospital, Basel, Switzerland · Chicago, Illinois and 24 other locations · NCT07777744

• Visioning III: Five-year follow-up for MRI-based prostate cancer screening

  This study tests a repeat MRI-based screening approach for men who previously had no cancer signs, to see if a negative bpMRI reliably predicts no significant cancer for at least five years.

  Recruiting University Hospital, Basel, Switzerland · Basel, Canton of Basel-City · NCT07762911

• Oxytocin in postmenopausal and premenopausal women

  Researchers will test whether cumulative endogenous neurophysin I, a surrogate for oxytocin, differs over a month between premenopausal and postmenopausal women.

  Recruiting University Hospital, Basel, Switzerland · Basel, Canton of Basel-City · NCT07742124

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.