Propofol IV versus sevoflurane inhaled anesthesia during mechanical thrombectomy for acute ischemic stroke
Prospective Randomized Observer Blinded Single Center Study Comparing 90-day Functional Outcome in Patients Who Received Intravenous Propofol Infusion Versus Inhalational Sevoflurane for General Anesthesia During Mechanical Thrombectomy in Patients Who Suffered From Acute Ischemic Stroke
This study will test whether IV propofol or inhaled sevoflurane during general anesthesia leads to better 90-day recovery for adults having a mechanical thrombectomy for acute ischemic stroke.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 120 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Kansas Medical Center Academic / other |
| Locations | 1 site (Kansas City, Kansas) |
| Trial ID | NCT07001267 on ClinicalTrials.gov |
What this trial studies
This single-center, prospective, randomized, observer-blinded trial at the University of Kansas Medical Center will compare 90-day functional outcomes in adults undergoing endovascular thrombectomy who receive either total intravenous anesthesia with propofol or inhalational anesthesia with sevoflurane. Eligible patients are adults (>18) presenting with acute ischemic stroke due to a large vessel occlusion who require mechanical thrombectomy and have no contraindications to either anesthetic technique. Patients will be randomized to one of the two anesthesia approaches during the procedure, with outcome assessors blinded to assignment and primary outcomes measured by 90-day functional disability scales. The protocol also captures procedural metrics and safety events to determine whether one technique yields lower disability and safer perioperative care.
Who should consider this trial
Good fit: Adults over 18 with an acute ischemic stroke requiring endovascular thrombectomy who have no contraindications to propofol or inhalational agents are the intended participants.
Not a fit: Patients who are pregnant, have malignant hyperthermia, allergies or other contraindications to either anesthetic, are already on IV anesthetic infusions, or are incarcerated or hospital staff/students are excluded and would not benefit from participation.
Why it matters
Potential benefit: If one anesthesia method produces better 90-day function, clinicians could adopt that technique to reduce long-term disability after thrombectomy.
How similar studies have performed: Previous studies comparing general anesthesia versus conscious sedation have shown mixed results with some suggestion of better recanalization under general anesthesia, but randomized head-to-head comparisons of inhalational anesthesia versus TIVA for thrombectomy are limited and this question remains relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * \>18 years Acute ischemic stroke requiring endovascular treatment. Exclusion Criteria: * \<18 years * Pregnant patients * Patients with malignant hyperthermia * Allergies or any contraindications to either inhalational or intravenous agents * Patients already on intravenous anesthetic infusions * Prisoners * Students and employees
Where this trial is running
Kansas City, Kansas
- University of Kansas Medical Center — Kansas City, Kansas, United States (Recruiting)
Study contacts
- Principal investigator: Arun George, MD — University of Kansas Medical Center
- Study coordinator: Arun George, MD
- Email: ageorge9@kumc.edu
- Phone: 913-588-6670
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.