Propofol IV versus sevoflurane inhaled anesthesia during mechanical thrombectomy for acute ischemic stroke
Official title: Prospective Randomized Observer Blinded Single Center Study Comparing 90-day Functional Outcome in Patients Who Received Intravenous Propofol Infusion Versus Inhalational Sevoflurane for General Anesthesia During Mechanical Thrombectomy in Patients Who Suffered From Acute Ischemic Stroke
Run by University of Kansas Medical Center · NCT07001267 · Data updated 2026-11-12
This study will test whether IV propofol or inhaled sevoflurane during general anesthesia leads to better 90-day recovery for adults having a mechanical thrombectomy for acute ischemic stroke.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 120 (estimated) |
| Sponsor | University of Kansas Medical Center Academic / other |
| Locations | 1 site (Kansas City, Kansas) |
| Status | Recruiting |
| Started | June 4, 2025 |
| Main results expected | May 31, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | March 12, 2026 |
| Trial ID | NCT07001267 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults over 18 with an acute ischemic stroke requiring endovascular thrombectomy who have no contraindications to propofol or inhalational agents are the intended participants.
✕Probably not a fit
Patients who are pregnant, have malignant hyperthermia, allergies or other contraindications to either anesthetic, are already on IV anesthetic infusions, or are incarcerated or hospital staff/students are excluded and would not benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This single-center, prospective, randomized, observer-blinded trial at the University of Kansas Medical Center will compare 90-day functional outcomes in adults undergoing endovascular thrombectomy who receive either total intravenous anesthesia with propofol or inhalational anesthesia with sevoflurane. Eligible patients are adults (>18) presenting with acute ischemic stroke due to a large vessel occlusion who require mechanical thrombectomy and have no contraindications to either anesthetic technique. Patients will be randomized to one of the two anesthesia approaches during the procedure, with outcome assessors blinded to assignment and primary outcomes measured by 90-day functional disability scales. The protocol also captures procedural metrics and safety events to determine whether one technique yields lower disability and safer perioperative care.
Why it matters
Potential benefit: If one anesthesia method produces better 90-day function, clinicians could adopt that technique to reduce long-term disability after thrombectomy.
How similar studies have gone: Previous studies comparing general anesthesia versus conscious sedation have shown mixed results with some suggestion of better recanalization under general anesthesia, but randomized head-to-head comparisons of inhalational anesthesia versus TIVA for thrombectomy are limited and this question remains relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * \>18 years Acute ischemic stroke requiring endovascular treatment. Exclusion Criteria: * \<18 years * Pregnant patients * Patients with malignant hyperthermia * Allergies or any contraindications to either inhalational or intravenous agents * Patients already on intravenous anesthetic infusions * Prisoners * Students and employees
Where it's running
-
University of Kansas Medical Center
Kansas City, Kansas, United States Recruiting
Study contacts
- Principal investigator: Arun George, MD — University of Kansas Medical Center
- Study coordinator: Arun George, MD
- Email: ageorge9@kumc.edu
- Phone: 913-588-6670
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.