Progressive gait training for people after a first lower‑leg deep vein thrombosis
Progressive Gait Training After First-time Deep Venous Thrombosis: Clinical Effectiveness and Involved Mecanisms (The DVT-Cph RCT)
This will test if adding progressive walking (gait) training to standard care improves quality of life for adults after a first lower‑extremity DVT.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 152 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Hvidovre University Hospital Academic / other |
| Locations | 1 site (Hvidovre, Capital Region) |
| Trial ID | NCT06909240 on ClinicalTrials.gov |
What this trial studies
This randomized controlled trial will enroll adults hospitalized with a first lower‑extremity DVT and randomly assign them to progressive gait training plus standard care or to standard care alone. The primary clinical aim is to test whether the added progressive walking program improves quality of life, while mechanistic aims track disease progression, post‑thrombotic syndrome, and severity of venous thromboembolism. A preceding feasibility trial will examine intervention practicality and patient experiences, and participants may also join a parallel cohort studying inflammatory, immunological, and ageing biomarkers. The trial is led by Hvidovre University Hospital in the Capital Region of Denmark.
Who should consider this trial
Good fit: Adults (18+) hospitalized with a first‑time lower‑extremity DVT who have a Danish social security number, can cooperate cognitively and physically, and understand Danish.
Not a fit: Patients with terminal illness, those who cannot understand Danish, or those without a Danish social security number are not eligible and therefore would not be expected to benefit from participation.
Why it matters
Potential benefit: If successful, the intervention could improve patient quality of life and reduce long‑term complications such as post‑thrombotic syndrome.
How similar studies have performed: Exercise and rehabilitation interventions after DVT have limited prior data with some small studies suggesting symptomatic or mobility benefits, but progressive gait training for first‑time DVT is relatively novel and not yet proven.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years or above * First time lower extremity DVT * Hospitalized at the Emergency Department * Can cooperate cognitively and physically (patient reported) Exclusion Criteria: * Patients without a Danish social security number * Terminal patients * Patients who do not understand or speak Danish
Where this trial is running
Hvidovre, Capital Region
- Hvidovre University Hospital — Hvidovre, Capital Region, Denmark (Recruiting)
Study contacts
- Principal investigator: Helle Juul-Larsen, Ph.D. — Hvidovre University Hospital
- Study coordinator: Mette Merete Pedersen, Ph.D.
- Email: mette.merete.pedersen@regionh.dk
- Phone: +4538623350
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.