Programmed weaning from noninvasive ventilation for COPD exacerbations
Randomized Controlled Study of Programmed Weaning From Noninvasive Mechanical Ventilation for Acute Exacerbation of Chronic Obstructive Pulmonary Disease
This study is testing a new way to gradually stop using noninvasive ventilation for patients with COPD flare-ups to see if it helps them recover faster and stay out of the hospital longer.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 40 Years and up |
| Sex | All |
| Sponsor | Peking University Third Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Trial ID | NCT06014034 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates a programmed approach to withdrawing noninvasive ventilation (NIV) in patients experiencing acute exacerbations of chronic obstructive pulmonary disease (COPD). Patients admitted to the intensive care unit will be randomly assigned to either a programmed withdrawal group or a traditional withdrawal group, where the physician determines the NIV regimen. The study aims to evaluate the effectiveness of the programmed approach in reducing the duration of NIV and improving patient outcomes, including length of hospital stay and the need for invasive ventilation. Primary endpoints include the successful transition from NIV to normal ventilation.
Who should consider this trial
Good fit: Ideal candidates are adults aged 40 and older with acute exacerbations of COPD who are experiencing respiratory acidosis and can tolerate noninvasive mechanical ventilation.
Not a fit: Patients under 40 years old, pregnant women, or those with significant comorbidities such as hemodynamic instability or HIV may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to shorter hospital stays and improved recovery for patients with acute COPD exacerbations.
How similar studies have performed: Previous studies have shown promise in using structured weaning protocols for NIV, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * It is defined that in patients with acute exacerbation of chronic obstructive pulmonary disease, the arterial blood gas analysis was decompensation of respiratory acidosis, and the pH value was 7.20-7.35 * Non-invasive mechanical ventilation was performed and it was well tolerated Exclusion Criteria: * younger than 40 years old * pregnancy * Human immunodeficiency virus (HIV) antibody was positive * Hemodynamic instability * Mechanical ventilation for endotracheal intubation and cardiopulmonary resuscitation were disagreed
Where this trial is running
Beijing, Beijing Municipality
- Peking University Third Hospita — Beijing, Beijing Municipality, China (Recruiting)
Study contacts
- Principal investigator: Qingtao Zhou — Peking University Third Hospital
- Study coordinator: Feifan Zhao
- Email: 112947952@qq.com
- Phone: +86-10-82265562
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.