Program to enhance heart health in patients getting stem cell transplants

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates a Cardio-Oncology Prehabilitation program aimed at improving cardiorespiratory fitness and reducing cardiovascular complications in high-risk patients undergoing hematopoietic stem cell transplantation. It focuses on patients with existing cardiovascular risk factors and assesses the feasibility and preliminary effectiveness of the intervention. Participants will engage in a structured program designed to enhance their cardiovascular health before the transplant procedure.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult 18 years or older
* Referred for HSCT evaluation
* Presence of least one CV risk factor at enrollment (hypertension, hyperlipidemia, atrial fibrillation, obesity, heart failure, history of coronary artery disease, diabetes)
* Able to ambulate unassisted
* Ability to understand and the willingness to sign a written informed consent
* Ability to use Polar Flow heart rate application

Exclusion Criteria:

* Severe anemia (hemoglobin \<7 gm/dl)
* Untreated high-risk coronary artery disease (left main, triple vessel disease)
* Severe aortic stenosis
* Recent fracture as assessed via self-report
* Gross balance deficits
* Severe pain with basic movement
* Unable to ambulate unassisted or exercise
* NYHA class IV heart failure
* Adults unable to give consent, pregnant women, and prisoners are excluded from this study.

Where it's running

• University of Michigan Rogel Cancer Center
  Ann Arbor, Michigan, United States Recruiting

Study contacts

• Principal investigator: Salim Hayek — University of Michigan Rogel Cancer Center
• Study coordinator: Cancer AnswerLine
• Email: CancerAnswerLine@med.umich.edu
• Phone: 1-800-865-1125

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Coping skills training for patients after stem cell transplant

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• Preventing GvHD in patients with blood cancers undergoing stem cell transplants

  This study is testing a new treatment called TRX-103 to see if it can help prevent graft-versus-host disease in people with blood cancers who are getting stem cell transplants from mismatched donors.

  Recruiting at 5 sites Phase 1 Tr1X, Inc. · Duarte, California and 4 other locations · NCT06462365

• Positive psychology support for survivors of stem cell transplants

  This study is testing a new program that helps people who have had stem cell transplants feel happier and less anxious by encouraging them to do enjoyable activities.

  Recruiting at 3 sites Brigham and Women's Hospital · Tampa, Florida and 2 other locations · NCT06328127

• T Cell Therapy for Cytomegalovirus Infections

  This study is testing whether using special immune cells from donors can help patients who had a stem cell transplant fight off cytomegalovirus infections.

  Recruiting Early Phase 1 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT02982902

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.