Profiling microbiome and metabolites in children with obstructive sleep apnea

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the differences in microbiome composition and urine metabolomic profiles between children aged 6-11 with obstructive sleep apnea (OSA) and those without. By comparing nasal and stool samples, as well as urine metabolites, the study seeks to uncover potential pathological processes associated with OSA. The hypothesis is that children with OSA will exhibit distinct microbiome and metabolomic profiles compared to non-OSA controls, which may be linked to inflammatory responses. This research could provide insights into the underlying mechanisms of OSA and its related health impacts.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Children aged 6-11 years old

Exclusion Criteria:

* Previous upper airway surgery, genetic or syndromal disease, congenital or acquired neuromuscular disease, suspected or confirmed congenital or acquired immunodeficiency, known metabolic syndrome, craniofacial abnormalities, structural or congenital heart disease, use of medications or therapy that could affect immunity such as systemic corticosteroids, chemotherapy, radiation therapy, intravenous immunoglobulins.

Where it's running

• Prince of Wales Hospital
  Hong Kong, Hong Kong Recruiting

Study contacts

• Principal investigator: Kate Ching Ching Chan, MD — Chinese University of Hong Kong
• Study coordinator: Kate Ching Ching Chan, MD
• Email: katechan@cuhk.edu.hk
• Phone: 35053515

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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• CES-EES score and a wearable ring for diagnosing obstructive sleep apnea

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.