Profiling imaging factors in prostate cancer treatment outcomes
Official title: Profiling of Radiological Factors in Treatment and Outcomes in Prostate Cancer
Run by National Institutes of Health Clinical Center (CC) · NCT03354416 · Data updated 2026-11-12
This study is trying to see if special MRI scans can help doctors better understand and treat prostate cancer in men aged 18 and older.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | Men only |
| Enrollment | 10000 (estimated) |
| Sponsor | National Institutes of Health Clinical Center (CC) NIH |
| Locations | 1 site (Bethesda, Maryland) |
| Status | Recruiting |
| Started | February 26, 2018 |
| Main results expected | December 31, 2030 |
| Study ends | December 31, 2033 |
| Registry record updated | October 16, 2026 |
| Trial ID | NCT03354416 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include men aged 18 and older with a diagnosis of prostate cancer or those at increased risk due to family history or genetic factors.
✕Probably not a fit
Patients without prostate cancer or those who do not meet the eligibility criteria may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to gather data on the radiological and clinical progression of prostate cancer by utilizing multiparametric MRI (mpMRI) to identify imaging-based prognostic markers. Participants, men aged 18 and older with diagnosed or suspected prostate cancer, will allow researchers to access their medical history and imaging results for analysis. The goal is to enhance diagnosis and treatment decisions through the development of a decision-support system that incorporates imaging and clinical data.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic accuracy and treatment strategies for prostate cancer patients.
How similar studies have gone: Other studies utilizing imaging-based biomarkers in prostate cancer have shown promise, indicating potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
* INCLUSION CRITERIA: * Patients with an increased risk for prostate cancer (strong family history and/or germline mutation in DNA repair genes), or with a diagnosis of prostatic cancer or suspicious for prostatic cancer lesions. * Age greater than or equal to 18 years * Ability of subject to understand and the willingness to sign a written informed consent document. EXCLUSION CRITERIA: -none
Where it's running
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National Institutes of Health Clinical Center
Bethesda, Maryland, United States Recruiting
Study contacts
- Principal investigator: Ismail B Turkbey, M.D. — National Cancer Institute (NCI)
- Study coordinator: Yolanda L McKinney, R.N.
- Email: ymckinney@mail.nih.gov
- Phone: (240) 760-6095
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Using a new type of PET scanner for imaging prostate cancer and related conditions
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Investigating prostate medication effects on gut microbiota
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Comparing two versus five MRI-guided treatments for prostate cancer
This study is testing if giving radiation treatment for prostate cancer in just two sessions instead of five can work just as well for men with localized prostate cancer.
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Collecting blood samples from prostate cancer patients
This study is collecting blood samples from men with prostate cancer to see if genetic differences affect how the disease progresses.
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Targeted alpha therapy for B7-H3 expressing solid tumors using AKY-2519
This phase 1b trial tests a radiolabeled drug (AKY-2519) to see if it's safe and tolerable in adults with B7-H3 positive advanced solid tumors, including NSCLC and SCLC, with imaging to help guide use.
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PSMA-guided surgery and tissue-resident T cells in node-positive prostate cancer
This study tests whether PSMA-guided surgery can help identify and study tissue-resident T cells in prostate cancer that has spread to lymph nodes.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.