Probiotics to reduce weight gain from antipsychotic medications

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of probiotic supplementation in reducing weight gain associated with atypical antipsychotic medications in adult patients diagnosed with schizophrenia. The study will involve a randomized controlled design, where participants will receive lactobacillus LS to assess its impact on weight and psychological well-being. The primary objective is to evaluate the reduction in weight gain, while the secondary objective focuses on the psychological state of the patients. The trial aims to enhance treatment compliance and overall quality of life for patients on antipsychotic medications.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult schizophrenia patients (18-45 years) on second generation antipsychotics Stable patients with a total positive and negative syndrome scale (PANSS) score of ≤60.

With more than 10% weight gain after taking atypical antipsychotics for at least 3 months with treatment duration not more than two years.

Exclusion Criteria:

1. Taking probiotics, fiber supplements, antibiotics and laxatives in the last 6 weeks.
2. Comorbid gastrointestinal diseases, including active peptic ulcer, uncontrolled and recurrent diarrhea, gastrointestinal bleeding, and digestive system neoplastic diseases.

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Where it's running

• AinShams university hospitals
  Cairo, Abbassia, Egypt Recruiting

Study contacts

• Study coordinator: Rehab Abdelmaksoud
• Email: rehab.abdelmaksoud@med.asu.edu.eg
• Phone: 02 01158336110

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.