Probiotics improving intestinal barrier function
Effects of DL-endopeptidase Produced by Probiotics on Human Intestinal NOD2 Ligands and Related Functions
This study is testing whether a special probiotic can help improve gut health by repairing the intestinal barrier in people with digestive issues.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Sex | All |
| Sponsor | Zhujiang Hospital Academic / other |
| Locations | 1 site (Canton, Guangzhou) |
| Trial ID | NCT06716047 on ClinicalTrials.gov |
What this trial studies
This trial investigates the effects of a specific probiotic that produces DL-endopeptidase on human intestinal health. Participants will take the probiotic orally for a designated period, during which blood and stool samples will be collected, along with questionnaires to assess efficacy and safety. The study aims to evaluate how this probiotic can repair the intestinal barrier and regulate enteritis, contributing to overall gut health.
Who should consider this trial
Good fit: Ideal candidates are individuals interested in improving their gut health and who meet the inclusion criteria.
Not a fit: Patients with severe digestive symptoms or chronic diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this could enhance gut health and improve intestinal barrier function for patients.
How similar studies have performed: Other studies have shown promising results with probiotics in gut health, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * tend to participate the trial Exclusion Criteria: * severe digestive symptoms, such as severe vomiting, hematochezia, bloody or tarry stool within one month before intervention; antibiotics or laxatives or probiotics or intestinal antiulcer agent within one month before intervention; previous or current treatment for any diseases or illnesses such as gastrointestinal disease (gastric ulcers, Crohn's, celiac, ulcerative colitis, etc.); other chronic diseases (diabetes, kidney disease, etc.) or immunecompromising diseases or conditions (HIV/AIDS, autoimmune, hepatitis, cancer, transplant patient etc.); pregnant or lactating.
Where this trial is running
Canton, Guangzhou
- Industrial Avenue 253, canton — Canton, Guangzhou, China (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.