Probiotics for Reducing Blue Light Eye Strain
Official title: The Application of Lactic Acid Bacteria on Reducing Blue Light-Induced Eye Fatigue in Middle-Aged Adults
Run by Synbio Tech Inc. · NCT07737938 · Data updated 2026-11-12
This study tests whether specific probiotic blends can reduce eye fatigue in adults who use screens a lot.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years to 65 Years |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | Synbio Tech Inc. Industry-sponsored |
| Locations | 1 site (Taipei) |
| Status | Recruiting |
| Started | September 4, 2026 |
| Main results expected | August 31, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | November 2, 2026 |
| Trial ID | NCT07737938 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 20-65 who use screens for more than 6 hours daily and have at least mild to severe digital eye strain.
✕Probably not a fit
Individuals with significant eye disease or recent probiotic use may not experience benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized, double-blind, placebo-controlled trial will evaluate whether two probiotic strains, Bifidobacterium longum BL531 and Lactobacillus reuteri LR1349, reduce digital eye strain symptoms in adults who use digital devices for long periods. Participants will be assigned to placebo or varying doses of the probiotic blends and followed to see if symptoms improve. The study aims to understand whether modulating the gut-eye axis can help relieve eye discomfort linked to screen use. The primary outcomes focus on changes in standard eye-strain scores and dry-eye symptoms. The trial is conducted at National Taiwan Normal University with Synbio Tech Inc. as the lead sponsor.
Why it matters
Potential benefit: If successful, participants may experience less eye fatigue and dryness during screen use.
How similar studies have gone: Prior research suggests gut microbiota can influence inflammatory and oxidative stress pathways affecting the eye, but direct benefits for DES are still being explored.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men and women aged 20-65 years * Daily digital screen use \>6 hours for at least 1 year * Mild to severe digital eye strain (CVS-Q score ≥ 6) * Mild to moderate dry eye symptoms (OSDI ≥ 13) Exclusion Criteria: * Amblyopia or strabismus * Severe eye diseases (e.g., glaucoma , cataract , retinal disorders, severe corneal disease) * Ocular surgery within the past 12 months * Chronic systemic diseases (e.g., uncontrolled diabetes, autoimmune disease, severe liver/kidney impairment, cancer) * Recent use (\<1 months) of steroids, antibiotics, immunosuppressants, probiotics, prebiotics, or eye-health supplements * Pregnant or breastfeeding * Allergy to probiotics or study product ingredients * Eating disorders, psychiatric illness, or cognitive impairment affecting compliance * Any condition judged unsuitable by the investigator
Where it's running
-
National Taiwan Normal University
Taipei, Taiwan Recruiting
Study contacts
- Study coordinator: Han-Yin Hsu
- Email: hanin@synbiotech.com.tw
- Phone: +886-07-6955680 Ext. 2923
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This test will see if an oral astaxanthin capsule can reduce digital eye strain symptoms in children who use electronic devices.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.