Probe compression after transrectal prostate biopsy to reduce bleeding and infection

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial compares routine probe compression and different compression durations applied immediately after transrectal ultrasound-guided prostate biopsy to measure rates of hematuria, rectal bleeding, and infectious complications. Eligible men are age 18 or older undergoing their first transrectal biopsy who can provide informed consent and appropriately manage anticoagulation; key exclusions include uncorrectable coagulopathy, active urinary tract infection, or acute anorectal conditions. The intervention uses short-duration ultrasound-guided rectal probe compression (with predefined time intervals) versus usual care, and participants are followed for clinically significant bleeding events and post-biopsy infections. The trial is conducted at Veterans Health Service Medical Center in Seoul with randomized allocation and standardized outcome monitoring.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male patients aged ≥18 years
* Scheduled to undergo transrectal ultrasound-guided prostate biopsy
* Biopsy-naïve patients (first-time prostate biopsy)
* Able to provide written informed consent

Exclusion Criteria:

* Uncorrectable coagulopathy or bleeding disorder
* Active urinary tract infection at the time of biopsy
* Acute anorectal conditions (e.g., hemorrhoidal bleeding, anal fissure, proctitis)
* Inability to discontinue or appropriately manage anticoagulant or antiplatelet therapy
* History of severe drug allergy or hypersensitivity to medications used in the study
* Individuals unable to provide informed consent (e.g., cognitive impairment, medically incapacitated) or other vulnerable populations
* Participation in another interventional study related to prostate disease that may interfere with the outcomes of this study
* Severe comorbid conditions limiting study participation
* Inability to comply with follow-up procedures

Where it's running

• VHS medical center
  Seoul, Seoul, South Korea Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.