Proactive health care pathway for Parkinson's patients starting apomorphine infusion

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates a proactive care pathway designed to enhance patient autonomy during the initiation of continuous subcutaneous apomorphine infusion in individuals with advanced Parkinson's disease. The program combines therapeutic education, modifications to hospital procedures, and improved coordination between hospital and community care. The primary goal is to assess the impact of this pathway on patient autonomy after six months, while also measuring various clinical and economic outcomes. The study aims to empower patients and their caregivers to manage treatment more effectively.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient of legal age;
* Affiliated to the social security;
* Parkinson's disease according to the diagnostic criteria of the UK Parkinson's disease society brain bank clinical diagnostic criteria;
* Presence of disabling motor fluctuations and/or dyskinesia despite optimized oral treatment (MDS-UPDRS IV item \>2)
* Patient eligible for and accepting apomorphine pump therapy
* Autonomous patient (Hoehn and Yahr stage \< 4);
* No significant cognitive impairment (MoCA \>= 25)
* Patient can be autonomous on the daily management of the pump according to the investigator's opinion.
* Patient having signed an informed consent

Exclusion Criteria:

* Significant cognitive impairment (MoCA score \<25);
* Major depressive episode, uncontrolled at the time of assessment (BDI\>25) or bipolar disorder;
* Active visual hallucinations or history of severe hallucination episodes;
* Previous apomorphine pump use;
* History of respiratory distress;
* History of severe impulse control disorders;
* Patient and/or caregiver who cannot be empowered in the opinion of the investigator.
* Protected persons, curators, persons under court protection, persons deprived of liberty by judicial or administrative decision, persons under forced psychiatric care and persons admitted to a health or social institution for purposes other than those of the research

Where it's running

• Ap-Hm
  Marseille, France Recruiting

Study contacts

• Study coordinator: Guillaume HACHE
• Email: guillaume.hache@ap-hm.fr
• Phone: (0)4 91 38 43 98

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.