Prism training with or without TENS to reduce one-sided neglect after stroke
A Comparison of Prism Adaptation Training (PAT) Paired With Transcutaneous Electrical Stimulation (TENS) vs PAT Alone on Outcomes in Post-Stroke Patients Experiencing Unilateral Spatial Neglect (USN)
This project tests whether adding mild electrical stimulation (TENS) to prism adaptation training helps people with one-sided neglect after stroke pay better attention to their affected side than prism training alone.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Kettering Health Network Academic / other |
| Locations | 2 sites (Centerville, Ohio and 1 other locations) |
| Trial ID | NCT07157865 on ClinicalTrials.gov |
What this trial studies
Adults with unilateral spatial neglect after stroke will receive prism adaptation training either alone or combined with transcutaneous electrical nerve stimulation (TENS). Trained therapists will deliver the interventions at the Kettering Health NeuroRehab and Balance Center and measure outcomes before and after the treatment course. Primary and secondary outcomes include the Catherine Bergego Scale for neglect severity and the Wolf Motor Function Test for affected arm function, with follow-up to track durability. Investigators will also examine whether age, time since stroke, lesion location, or baseline neglect severity influence response.
Who should consider this trial
Good fit: Ideal candidates are stroke survivors who show at least mild unilateral spatial neglect (Catherine Bergego Scale score ≥1), are cognitively able to consent, and have preserved sensation in the affected upper limb.
Not a fit: Patients with seizure disorders, more than two prior strokes, pacemakers or defibrillators, absent sensation in the affected arm, schizophrenia/schizoaffective disorder, or active upper-extremity cancer are unlikely to be eligible or to benefit from this protocol.
Why it matters
Potential benefit: If successful, the combined treatment could lead to greater attention to the neglected side and improved use of the affected arm, speeding functional recovery.
How similar studies have performed: Prism adaptation training has demonstrated benefit for unilateral neglect in multiple studies, while combining PAT with TENS is less well studied and represents a novel augmentation approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * A diagnosis of stroke * Score 1 or above on the Catherine Bergego Scale * Cognitively able to consent Exclusion Criteria: * Seizure disorder * Diagnosed with more than two strokes * Diagnosis of schizophrenia or schizoaffective disorder * Cancer diagnosis of upper extremity * Individuals with pacemakers and debrillators * Absent sensation of upper extremity affected by stroke
Where this trial is running
Centerville, Ohio and 1 other locations
- Kettering Health NeuroRehab and Balance Center — Centerville, Ohio, United States (Not_yet_recruiting)
- Kettering Health NeuroRehab and Balance Center — Centerville, Ohio, United States (Recruiting)
Study contacts
- Principal investigator: Rachelle M Janning, OTD, MS, OTR/L — Kettering Health/Northern Kentucky University
- Study coordinator: Rachelle M Janning, OTD, MS, OTR/L
- Email: rachelle.janning@ketteringhealth.org
- Phone: 19372324443
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.