Prism training with or without TENS to reduce one-sided neglect after stroke
Official title: A Comparison of Prism Adaptation Training (PAT) Paired With Transcutaneous Electrical Stimulation (TENS) vs PAT Alone on Outcomes in Post-Stroke Patients Experiencing Unilateral Spatial Neglect (USN)
Run by Kettering Health Network · NCT07157865 · Data updated 2026-11-12
This project tests whether adding mild electrical stimulation (TENS) to prism adaptation training helps people with one-sided neglect after stroke pay better attention to their affected side than prism training alone.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | Kettering Health Network Academic / other |
| Locations | 2 sites (Centerville, Ohio and 1 other locations) |
| Status | Recruiting |
| Started | September 30, 2025 |
| Main results expected | September 30, 2028 |
| Study ends | September 30, 2028 |
| Registry record updated | March 23, 2026 |
| Trial ID | NCT07157865 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are stroke survivors who show at least mild unilateral spatial neglect (Catherine Bergego Scale score ≥1), are cognitively able to consent, and have preserved sensation in the affected upper limb.
✕Probably not a fit
Patients with seizure disorders, more than two prior strokes, pacemakers or defibrillators, absent sensation in the affected arm, schizophrenia/schizoaffective disorder, or active upper-extremity cancer are unlikely to be eligible or to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults with unilateral spatial neglect after stroke will receive prism adaptation training either alone or combined with transcutaneous electrical nerve stimulation (TENS). Trained therapists will deliver the interventions at the Kettering Health NeuroRehab and Balance Center and measure outcomes before and after the treatment course. Primary and secondary outcomes include the Catherine Bergego Scale for neglect severity and the Wolf Motor Function Test for affected arm function, with follow-up to track durability. Investigators will also examine whether age, time since stroke, lesion location, or baseline neglect severity influence response.
Why it matters
Potential benefit: If successful, the combined treatment could lead to greater attention to the neglected side and improved use of the affected arm, speeding functional recovery.
How similar studies have gone: Prism adaptation training has demonstrated benefit for unilateral neglect in multiple studies, while combining PAT with TENS is less well studied and represents a novel augmentation approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * A diagnosis of stroke * Score 1 or above on the Catherine Bergego Scale * Cognitively able to consent Exclusion Criteria: * Seizure disorder * Diagnosed with more than two strokes * Diagnosis of schizophrenia or schizoaffective disorder * Cancer diagnosis of upper extremity * Individuals with pacemakers and debrillators * Absent sensation of upper extremity affected by stroke
Where it's running
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Kettering Health NeuroRehab and Balance Center
Centerville, Ohio, United States Recruiting -
Kettering Health NeuroRehab and Balance Center
Centerville, Ohio, United States Not yet recruiting
Study contacts
- Principal investigator: Rachelle M Janning, OTD, MS, OTR/L — Kettering Health/Northern Kentucky University
- Study coordinator: Rachelle M Janning, OTD, MS, OTR/L
- Email: rachelle.janning@ketteringhealth.org
- Phone: 19372324443
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.