Primary versus secondary ILM peeling for rhegmatogenous retinal detachment
Official title: Primary Versus Secondary Internal Limiting Membrane Peeling in Uncomplicated Retinal Detachment
Run by Sohag University · NCT07346560 · Data updated 2026-11-12
This trial will test whether peeling the internal limiting membrane (ILM) during the first vitrectomy or waiting until silicone oil removal leads to better vision and fewer complications for people with uncomplicated rhegmatogenous retinal detachment.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Sohag University Academic / other |
| Locations | 1 site (Sohag, Sohag Governorate) |
| Status | Recruiting |
| Started | December 15, 2025 |
| Main results expected | December 2026 |
| Study ends | March 2027 |
| Registry record updated | January 16, 2026 |
| Trial ID | NCT07346560 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are people with uncomplicated rhegmatogenous retinal detachment who have not had prior vitrectomy and do not have proliferative vitreoretinopathy, macular scarring, or other exclusionary conditions.
✕Probably not a fit
Patients with PVR, recurrent or tractional retinal detachment, macular hole detachment, those needing scleral buckle, macular scarring, or prior PPV are excluded and unlikely to benefit from this comparison.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Patients with uncomplicated rhegmatogenous retinal detachment will all undergo 23-gauge pars plana vitrectomy with silicone oil tamponade and then be assigned to one of two groups based on when the ILM is peeled. Group A will have ILM peeling during the initial vitrectomy, while Group B will have ILM peeling later at the time of silicone oil extraction. Outcomes will include anatomical reattachment, visual acuity, rates of epiretinal membrane or proliferative vitreoretinopathy, and need for further surgery. The comparison aims to determine whether timing of ILM peeling affects vision and complication rates.
Why it matters
Potential benefit: If successful, the finding could improve final visual outcomes and reduce reoperations or membrane-related complications after repair of uncomplicated retinal detachment.
How similar studies have gone: Previous studies have examined ILM peeling to reduce epiretinal membranes and PVR with mixed results, but head-to-head comparisons of primary versus secondary peeling are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with uncomplicated rhegmatogenous retinal detcahment. Exclusion Criteria: * PVR * Recurrent RD * Tractional RD * Macular hole RD * Scleral buckling is indicated * Macular scarring * Previous PPV
Where it's running
-
Sohag Faculty of Medicine
Sohag, Sohag Governorate, Egypt Recruiting
Study contacts
- Study coordinator: Alaa Sinjab, MD
- Email: alaa.abdelsadek@med.sohag.edu.eg
- Phone: +20-01064037382
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Closure of a macular hole with Tenon capsule graft versus ILM flap
This pilot study tests whether using a piece of the patient’s Tenon capsule can help close a macular hole as well as or better than the standard ILM flap technique.
-
Trauma registry at Sohag University Hospital
This study tests the creation of a trauma registry in the emergency department to collect data on injured adults admitted with polytrauma at Sohag University Hospital.
-
Prevalence of Myocardial Bridging and its relation to Coronary Plaques on MDCT
This study tests how common myocardial bridging is and whether it relates to coronary plaque in patients undergoing coronary CT angiography.
-
Septoplasty: see if it changes headache symptoms
This study tests whether septoplasty can change headache severity in adults with septal deviation and headache.
-
Predicting SLE Flares with Patient Reports and Machine Learning
Aims to test a low-cost, patient-reported outcome–based machine learning tool to see if it can detect lupus flares early and support care, especially in settings with limited resources.
-
Is geographic mismatch linked to short-term major heart problems after long drug-eluting stent placement?
This study checks whether geographic mismatch can predict short-term major adverse cardiovascular events after a long drug-eluting stent is placed in the coronary arteries.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.