Preventing pre-eclampsia with low-dose aspirin in women after frozen embryo transfer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial is a prospective, multicentric, interventional randomized controlled trial aimed at evaluating the effectiveness of low-dose acetylsalicylic acid as a preventive treatment for pre-eclampsia in pregnant women who have undergone frozen embryo transfer. Participants will be randomly assigned to receive either the treatment or no treatment after confirming an intrauterine pregnancy at six weeks. The primary goal is to assess the incidence of pre-eclampsia in both groups, with regular follow-ups to monitor health outcomes throughout the pregnancy. The study will include women aged 18 to 43 who meet specific eligibility criteria and have provided informed consent.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy women from \[18 - 43\] years-old, planned for a frozen embryo transfer, with natural and modified natural or HRT cycle
* Who have given their informed consent
* Who have a confirmed pregnancy at week 6 of amenorrhea.

Exclusion Criteria:

* Women presenting one risk factor for preeclampsia: multiple pregnancy, history of preeclampsia, BMI \> 30, lupus syndrome, preexistent proteinuria, non-treated chronic high blood pressure (\>140/90), antiphospholipid antibody syndrome, diabetes (fasting blood sugar \>126mg/dl)
* Contraindication to acetylsalicylic acid (at risk of active hemorrhage (like hemophilia, …); at risk of or who have a gastro-duodenal ulcer; at risk or how have a terminal renal or hepatic in-sufficiency (only if acetylsalicylic acid is given at high dose)
* Already treated with acetylsalicylic acid
* Treatment with anticoagulants or non-steroid anti-inflammatory drugs

Where it's running

• Centre Hospitalier Universitaire de Liège site Citadelle
  Liège, Belgium Recruiting

Study contacts

• Principal investigator: Laurie Henry — Centre Hospitalier Régional de la Citadelle
• Study coordinator: Julie Collée
• Email: julie.collee@uliege.be
• Phone: +32498973386

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Effects of Corpus Luteum on Frozen Embryo Transfer Pregnancies

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.