Preventing pneumothorax during lung cancer treatment
Official title: Pleural Blood Patch for Lung Ablation: a Randomised Trial (Oxford Pleural Embolisation Trial - OxPET)
Run by Oxford University Hospitals NHS Trust · NCT06651658 · Data updated 2026-11-12
This study is testing if using a special technique called pleural blood patch can help prevent lung collapses in patients getting treatment for lung cancer.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 106 (estimated) |
| Sponsor | Oxford University Hospitals NHS Trust Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Oxford) |
| Status | Recruiting |
| Started | November 24, 2024 |
| Main results expected | December 31, 2026 |
| Study ends | September 2027 |
| Registry record updated | February 4, 2026 |
| Trial ID | NCT06651658 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older who are clinically indicated for lung ablation.
✕Probably not a fit
Patients who are unable to proceed with the lung ablation procedure or have three or more lung lesions to be ablated in the same setting may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This trial investigates the use of pleural embolization, specifically a technique known as pleural blood patch (PBP), to prevent pneumothorax in patients undergoing thermal ablation for lung cancer. Pneumothorax is a common complication that can lead to the need for chest drains, which are associated with additional morbidity. The study aims to assess the effectiveness of PBP in reducing the incidence of pneumothorax and the subsequent need for drainage procedures. By utilizing autologous blood to seal air leaks, the trial seeks to improve patient outcomes and recovery times following lung ablation.
Why it matters
Potential benefit: If successful, this approach could significantly reduce complications and improve recovery for patients undergoing lung cancer treatment.
How similar studies have gone: Previous studies have shown success with similar techniques in reducing pneumothorax rates during lung biopsies, indicating potential for this approach in lung ablation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinically indicated for lung ablation. * Willing and capable of giving informed consent. * Aged 18 years or above. Exclusion Criteria: * Unable to proceed to lung ablation procedure. * 3 or more lung lesions to be ablated in the same setting.
Where it's running
-
Oxford University Hospitals NHS Foundation Trust
Oxford, United Kingdom Recruiting
Study contacts
- Principal investigator: Dr Yan-Lin Li Consultant Interventional Radiologist, EBIR FRCR FHKAM — Oxford University Hospitals NHS Foundation Trust/ University of Oxford
- Study coordinator: Dr Yan-Lin Li Consultant Interventional Radiologist, EBIR FRCR FHKAM
- Email: yan-lin.li@ouh.nhs.uk
- Phone: 44 1865 235746
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.