Preventing Ovarian Hyperstimulation Syndrome in Women Undergoing IVF
Official title: Prophylaxis Against Ovarian Hyperstimulation Syndrome in PCOS Women
Run by Aljazeera Hospital · NCT06739759 · Data updated 2026-11-12
This study is testing a new way to prevent ovarian hyperstimulation syndrome in women with polycystic ovary syndrome who are undergoing IVF by using different treatment methods.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 19 Years to 42 Years |
| Sex | Women only |
| Enrollment | 300 (estimated) |
| Sponsor | Aljazeera Hospital Academic / other |
| Locations | 2 sites (Giza and 1 other locations) |
| Status | Recruiting |
| Started | November 17, 2024 |
| Main results expected | June 30, 2025 |
| Study ends | July 30, 2025 |
| Registry record updated | December 18, 2024 |
| Trial ID | NCT06739759 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are women with polycystic ovary syndrome (PCOS) who are preparing for intracytoplasmic sperm injection (ICSI).
✕Probably not a fit
Patients who do not have polycystic ovary syndrome (PCOS) may not receive any benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study focuses on preventing ovarian hyperstimulation syndrome (OHSS), a serious complication that can arise during in vitro fertilization (IVF) procedures, particularly in women with polycystic ovary syndrome (PCOS). The approach involves using an antagonist protocol for IVF and a modified agonist protocol, supplemented with additional treatments such as hydroxychloroquine (HCQ). By closely monitoring and adjusting treatment protocols, the study aims to reduce the incidence and severity of OHSS in affected patients.
Why it matters
Potential benefit: If successful, this study could significantly reduce the risk of OHSS in women undergoing IVF, improving their overall treatment experience and outcomes.
How similar studies have gone: While there have been studies addressing OHSS, the specific combination of protocols and treatments in this study may offer a novel approach that has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women with PCOS coming for ICSI Exclusion Criteria: * Women who donnot have PCOS
Where it's running
-
Aljazeerah hospital
Giza, Egypt Recruiting -
Algazeerah
Giza, Egypt Recruiting
Study contacts
- Study coordinator: Mahmoud Alalfy, MD
- Email: mahmoudalalfy@ymail.com
- Phone: 01002611058
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.