Preventing ovarian cancer during colorectal surgery
Preventing Ovarian Cancer Through the Expansion of Opportunistic Salpingectomy: Uptake, Safety and Cost-effectiveness at the Time of Colorectal Surgery
This study is testing if removing fallopian tubes during colorectal surgery can help prevent ovarian cancer for women having that surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 240 (estimated) |
| Ages | 15 Years to 80 Years |
| Sex | Female |
| Sponsor | University of British Columbia Academic / other |
| Locations | 2 sites (Vancouver, British Columbia and 1 other locations) |
| Trial ID | NCT05300711 on ClinicalTrials.gov |
What this trial studies
This study evaluates the feasibility, safety, and cost-effectiveness of opportunistic salpingectomy (OS), which involves the removal of fallopian tubes, performed concurrently with colorectal surgery to prevent ovarian cancer. The research will enroll 120 participants who will undergo OS and compare them to a control group of 120 participants who will have colorectal surgery without OS. The study aims to gather data on the consent rates for OS, the safety of the procedure, and the perspectives of patients who decline participation. The findings could inform future practices regarding ovarian cancer prevention during colorectal surgeries.
Who should consider this trial
Good fit: Ideal candidates are women with intact fallopian tubes who are undergoing specific types of colorectal surgery and have completed childbearing.
Not a fit: Patients with BRCA 1 or 2 mutations will not benefit from this study as they are excluded from participation.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the incidence of ovarian cancer in women undergoing colorectal surgery.
How similar studies have performed: While opportunistic salpingectomy has been shown to be safe and effective during gynecologic surgeries, this specific application during colorectal surgery is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Individuals with intact fallopian tubes. * Individuals undergoing one of the following open or laparoscopic colorectal surgery: total colectomy, right hemicolectomy, left hemicolectomy, anterior resection, low anterior resection, small bowel resection and appendectomy. * Individuals who finished with childbearing. Exclusion Criteria: * Presence of BRCA 1 or 2 mutation.
Where this trial is running
Vancouver, British Columbia and 1 other locations
- St. Paul's Hospital — Vancouver, British Columbia, Canada (Recruiting)
- Vancouver General Hospital — Vancouver, British Columbia, Canada (Not_yet_recruiting)
Study contacts
- Principal investigator: Gillian Hanley, PhD — University of British Columbia
- Study coordinator: Gillian Hanley, PhD
- Email: Gillian.Hanley@vch.ca
- Phone: 778-888-5822
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.