Preventing infections with vaccines in bone marrow and solid organ transplant patients
Factors Affecting Vaccine Prophylaxis Efficacy in Bone Marrow and Solid Organ Transplant Recipients: Impact on Infection and Mortality Rates
This project will try a vaccine-focused care pathway to increase vaccine coverage and see if it lowers infections and deaths in people getting solid organ or bone marrow transplants.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Sex | All |
| Sponsor | Fondazione IRCCS Policlinico San Matteo di Pavia Academic / other |
| Locations | 1 site (Pavia, Lombardy) |
| Trial ID | NCT07473999 on ClinicalTrials.gov |
What this trial studies
This observational program enrolls all patients eligible for solid organ transplantation (SOT) or bone marrow transplantation (BMT) at a single tertiary hospital and implements a dedicated vaccination care pathway before and after transplant. Vaccination status and delivery will be optimized according to clinical guidelines, with documentation of which vaccines are given and when. Patients who actually undergo SOT or BMT will be followed for vaccine-preventable infections and infection-related mortality over the post-transplant period. Data will be analyzed to compare vaccination coverage and clinical infection outcomes, informing a tailored prevention pathway for this high-risk population.
Who should consider this trial
Good fit: Any patient evaluated at the hospital who is eligible for solid organ or bone marrow transplantation and who consents to participate is eligible, with follow-up for those who undergo transplant.
Not a fit: Patients who decline consent or who have absolute contraindications to vaccination will not receive the intervention or potential benefit from the vaccination pathway.
Why it matters
Potential benefit: If successful, this approach could increase vaccination coverage and reduce vaccine-preventable infections and infection-related deaths among transplant recipients.
How similar studies have performed: Previous programs have shown improved vaccine uptake with tailored pre- and post-transplant vaccination pathways, but evidence of clear reductions in infection-related mortality in immunocompromised transplant populations remains limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Any patient eligible for SOT or BMT evaluated in our hospital * Only patients undergoing SOT or BMT will be followed-up for infections Exclusion Criteria: * Already enrolled in the study * Denied informed consent * Absolute contraindication to vaccinations
Where this trial is running
Pavia, Lombardy
- Fondazione IRCCS Policlinico San Matteo di Pavia — Pavia, Lombardy, Italy (Recruiting)
Study contacts
- Study coordinator: Alba Muzzi
- Email: a.muzzi@smatteo.pv.it
- Phone: 0382/502268
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.