Preventing infections with vaccines in bone marrow and solid organ transplant patients
Official title: Factors Affecting Vaccine Prophylaxis Efficacy in Bone Marrow and Solid Organ Transplant Recipients: Impact on Infection and Mortality Rates
Run by Fondazione IRCCS Policlinico San Matteo di Pavia · NCT07473999 · Data updated 2026-11-12
This project will try a vaccine-focused care pathway to increase vaccine coverage and see if it lowers infections and deaths in people getting solid organ or bone marrow transplants.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Fondazione IRCCS Policlinico San Matteo di Pavia Academic / other |
| Locations | 1 site (Pavia, Lombardy) |
| Status | Recruiting |
| Started | September 13, 2019 |
| Main results expected | September 13, 2026 |
| Study ends | September 13, 2026 |
| Registry record updated | March 16, 2026 |
| Trial ID | NCT07473999 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Any patient evaluated at the hospital who is eligible for solid organ or bone marrow transplantation and who consents to participate is eligible, with follow-up for those who undergo transplant.
✕Probably not a fit
Patients who decline consent or who have absolute contraindications to vaccination will not receive the intervention or potential benefit from the vaccination pathway.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational program enrolls all patients eligible for solid organ transplantation (SOT) or bone marrow transplantation (BMT) at a single tertiary hospital and implements a dedicated vaccination care pathway before and after transplant. Vaccination status and delivery will be optimized according to clinical guidelines, with documentation of which vaccines are given and when. Patients who actually undergo SOT or BMT will be followed for vaccine-preventable infections and infection-related mortality over the post-transplant period. Data will be analyzed to compare vaccination coverage and clinical infection outcomes, informing a tailored prevention pathway for this high-risk population.
Why it matters
Potential benefit: If successful, this approach could increase vaccination coverage and reduce vaccine-preventable infections and infection-related deaths among transplant recipients.
How similar studies have gone: Previous programs have shown improved vaccine uptake with tailored pre- and post-transplant vaccination pathways, but evidence of clear reductions in infection-related mortality in immunocompromised transplant populations remains limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Any patient eligible for SOT or BMT evaluated in our hospital * Only patients undergoing SOT or BMT will be followed-up for infections Exclusion Criteria: * Already enrolled in the study * Denied informed consent * Absolute contraindication to vaccinations
Where it's running
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Fondazione IRCCS Policlinico San Matteo di Pavia
Pavia, Lombardy, Italy Recruiting
Study contacts
- Study coordinator: Alba Muzzi
- Email: a.muzzi@smatteo.pv.it
- Phone: 0382/502268
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.