Preventing infections after knee replacement surgery with vancomycin
Official title: Prospective, Randomized, Double Blinded Trial Comparing Clinical, Radiological and Laboratory Outcomes in Prevention of Infection After Total Knee Arthroplasty With or Without Vancomycin.
Run by Centre of Postgraduate Medical Education · NCT05461651 · Data updated 2026-11-12
This study is testing if using vancomycin during knee replacement surgery can help prevent infections after the operation.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 40 Years and up |
| Sex | All |
| Enrollment | 1800 (estimated) |
| Sponsor | Centre of Postgraduate Medical Education Academic / other |
| Locations | 1 site (Otwock, Masovian Voivodeship) |
| Status | Recruiting |
| Started | September 1, 2021 |
| Main results expected | January 1, 2028 |
| Study ends | January 1, 2029 |
| Registry record updated | July 18, 2022 |
| Trial ID | NCT05461651 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals diagnosed with gonarthrosis who are undergoing total knee arthroplasty.
✕Probably not a fit
Patients who may not benefit from this study include those under 40 years of age, those with multiligament injuries, or those with other significant musculoskeletal disorders.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial is a prospective, randomized, double-blinded investigation aimed at comparing the outcomes of infection prevention in patients undergoing total knee arthroplasty (TKA) with and without the use of vancomycin. The study will assess clinical, radiological, and laboratory outcomes to determine if adding vancomycin to the joint before wound closure can effectively reduce the incidence of postoperative infections. Participants will be monitored for infection rates following their surgery to evaluate the efficacy of the intervention.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the risk of infections following knee replacement surgeries, leading to better recovery outcomes for patients.
How similar studies have gone: While the use of vancomycin in surgical settings has been explored, this specific approach in total knee arthroplasty is novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Gosnartrosis Exclusion Criteria: * no informed consent to participate in the study age under 40 multilligament injury or single plane knee instability another musculoskeletal disorders in lower limb ASA score \> II
Where it's running
-
Department of Orthopaedics and Traumatology, Postgraduate Center for Medical Education, Professor A. Gruca Teaching Hospital
Otwock, Masovian Voivodeship, Poland Recruiting
Study contacts
- Study coordinator: Rafal Kaminski, MD PhD
- Email: rkaminski@spskgruca.pl
- Phone: 48 227754031
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
ESPB vs. IV lidocaine for pain after breast reduction
This study tests whether an ultrasound-guided erector spinae plane block plus intraoperative lidocaine helps reduce pain after breast reduction compared with intravenous lidocaine alone.
-
Intraoperative Lidocaine or Dexmedetomidine to Help Postoperative Pain After Urethral Reconstruction
This study tests whether giving lidocaine or dexmedetomidine during urethral reconstruction can reduce pain after surgery and lower the chance of long-lasting pain.
-
New method for treating reflex syncope using cardioneuroablation
This study is testing a new heart treatment called cardioneuroablation to see which of three methods works best for finding the right spots in the heart to help people with severe fainting spells.
-
Treatment for reflex syncope using cardioneuroablation
This study is testing if a new procedure called cardioneuroablation can help people with severe reflex syncope by improving their heart function and reducing fainting episodes.
-
Bipolar ablation for treating ventricular arrhythmias after unipolar failure
This study is testing if a new type of heart procedure called bipolar ablation can help patients with heart rhythm problems who didn't get better from an earlier treatment.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.