Preventing Catheter Problems with Prophylactic Enoxaparin in Critically Ill Children

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, randomized trial compares prophylactic enoxaparin to usual care in children requiring a central venous line in the PICU. Participants are randomized to receive prophylactic anticoagulation or standard care and followed for up to 30 days to assess catheter-related complications, bleeding, and infection. Outcomes include time to first catheter occlusion, rates of catheter-related thrombosis and CLABSI, number of catheter manipulations, dwell time, and need for thrombolysis or further anticoagulation. Data collection covers demographics, CVC characteristics, thrombotic events, anticoagulation details, laboratory tests, and imaging as clinically indicated. The study aims to inform whether prophylactic anticoagulation can improve catheter safety without unacceptable bleeding risk.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* All Children requiring a newly placed central venous line (peripherally inserted central catheter \[PICC\], or non-tunneled central venous catheter) for clinical care.

Exclusion Criteria:

* Known major congenital bleeding diathesis or platelet count \<50,000/µL at time of insertion.
* Already on therapeutic anticoagulation for another indication.
* Known heparin allergy or history of heparin-induced thrombocytopenia.
* Use of dialysis catheters (study focuses on standard CVCs/PICCs).

Where it's running

• Menoufia university hospital, Pediatric intensive care unit
  Shibīn al Kawm, Menoufia Governorate, Egypt Recruiting

Study contacts

• Principal investigator: Hani Hamed Saad, MD, pediatrics — Faculty of medicine, Menoufia University
• Study coordinator: Hani Hamed Saad, MD, Pediatrics
• Email: hani.hamed870@med.menofia.edu.eg
• Phone: +201067610619

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.