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Clinical trial Recruiting at 4 sites Interventional Ages 40 to 80

Preventing angle closure glaucoma in Caucasian patients

Official title: Danish Angle Closure Prevention Trial

Run by University of Aarhus · NCT06077253 · Data updated 2026-11-12

This study tests if a laser treatment can help prevent angle closure glaucoma from getting worse in Caucasian patients who are at risk.

Quick facts

Study typeInterventional
Ages40 Years to 80 Years
SexAll
Enrollment242 (estimated)
SponsorUniversity of Aarhus
Academic / other
Locations5 sites (Aalborg and 4 other locations)
StatusRecruiting
StartedSeptember 1, 2023
Main results expectedSeptember 1, 2029
Study endsSeptember 1, 2029
Registry record updatedNovember 13, 2023
Trial IDNCT06077253 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are Caucasian individuals identified as primary angle closure suspects with specific clinical criteria.

Probably not a fit

Patients with previous eye surgeries, existing glaucoma, or other significant ocular conditions may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness of prophylactic laser iridotomy in preventing the progression of primary angle closure suspects (PACS) in a Caucasian population. It employs a prospective, randomized paired-eye design, where one eye receives the laser treatment while the other is observed over a five-year follow-up period. The study will assess the outcomes based on the development of angle closure glaucoma and other related complications.

Why it matters

Potential benefit: If successful, this study could provide a preventive treatment option for patients at risk of developing angle closure glaucoma.

How similar studies have gone: Other studies have shown promising results with laser iridotomy in similar populations, indicating potential for success in this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Primary angle closure suspect: ≥180 degrees (cumulative) irido-trabecular contact on darkroom gonioscopy, IOP\<21mmHg, no peripheral anterior synechiae, no glaucomatous optic neuropathy
* Best-corrected visual acuity (BCVA) \>0.8 on both eyes
* Caucasian

Exclusion Criteria:

* Pseudophakia
* Previous iridotomy
* Clinically significant cataract with indication for surgery,
* Gaucoma
* Uveitis
* Unstable retinal conditions
* Ocular malignancies
* PEX
* PDS
* Systemic or ocular corticosteroid treatment

Where it's running

  • Aalborg University Hospital
    Aalborg, Denmark     Recruiting
  • Aarhus University Hospital
    Aarhus, Denmark     Recruiting
  • Rigshospitalet Glostrup
    Glostrup Municipality, Denmark     Recruiting
  • Sygehus Lillebælt
    Vejle, Denmark     Recruiting
  • Odense University Hospital
    Odense, Denmark     Not yet recruiting

Study contacts

  • Principal investigator: Niklas Telinius — Aarhus University Hospital
  • Study coordinator: Niklas Telinius, PhD, DMSc
  • Email: telinius@me.com
  • Phone: +4530238533

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.