Preventing adhesions after myomectomy surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of an intrauterine gel in preventing intrauterine adhesions following laparoscopic or laparotomic myomectomy in women aged 18 to 45 with specific types of myomas. It is a double-blind, randomized controlled pilot trial where participants will either receive the gel or a control treatment during their surgery. A follow-up hysteroscopy will be conducted three months post-surgery to assess adhesion formation. The study aims to improve fertility outcomes by reducing postoperative complications associated with myomectomy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* age between 18 and 45 years.
* intramurale and/or subserosal myoma (FIGO 3-6), and/or hybrid myoma (with a connection to the endometrium and serosa (FIGO 2-5), who are scheduled for laparoscopic / laparotomic myomectomy.
* absence of intra-uterine adhesions on preoperative diagnostic hysteroscopy

Exclusion Criteria:

* pregnancy.
* laparoscopic or laparotomic myomectomy in combination with an operative hysteroscopy.
* presence of endometritis.
* other antiadhesion methods

Where it's running

• University Hospital Ghent
  Ghent, Belgium Recruiting

Study contacts

• Study coordinator: Steffi Van Wessel, Dr.
• Email: studieco.vrouwenkliniek@uzgent.be
• Phone: 093320758

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Uterine artery ligation versus pericervical tourniquet to reduce bleeding during open myomectomy

  This trial will test whether tying the uterine arteries or using a pericervical tourniquet better reduces blood loss during open myomectomy for women with symptomatic uterine fibroids.

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• Ergometrine versus carbetocin to reduce bleeding during abdominal myomectomy

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• Temporary Clamping of Uterine and Ovarian Vessels During Minimally Invasive Myomectomy

  This study tests whether temporarily blocking blood flow from the uterine and ovarian arteries during minimally invasive myomectomy reduces blood loss for patients with large or multiple fibroids.

  Recruiting The University of Texas Health Science Center, Houston · Houston, Texas · NCT07182045

• Preventing bleeding during myomectomy with misoprostol

  This will test whether giving misoprostol before myomectomy reduces surgical bleeding in women aged 18–43 having surgery for symptomatic uterine fibroids.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand, Clermont-Ferrand · NCT06882824

• Comparing Terlipressin and Carbetocin for reducing blood loss during myomectomy

  This study is testing whether injections of Terlipressin or Carbetocin can help reduce blood loss during surgery to remove fibroids in women.

  Recruiting Wael Elbanna Clinic · Maadi · NCT05266534

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.