Preventing acute cholecystitis using endoscopic techniques
Official title: Efficacy of ETGBD Parallel Insertion With Fully Covered Self-expandable Metal Stent for Preventing Acute Cholecystitis in Patients With Low Cystic Duct Insertion
Run by Seoul National University Hospital · NCT06287112 · Data updated 2026-11-12
This study is testing if a new endoscopic technique can help prevent acute cholecystitis in patients with certain conditions better than standard care.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 19 Years and up |
| Sex | All |
| Enrollment | 35 (estimated) |
| Sponsor | Seoul National University Hospital Academic / other |
| Locations | 1 site (Seoul) |
| Status | Recruiting |
| Started | June 20, 2024 |
| Main results expected | February 20, 2027 |
| Study ends | March 30, 2027 |
| Registry record updated | February 20, 2025 |
| Trial ID | NCT06287112 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 19 and older with confirmed biliary obstruction and specific anatomical conditions.
✕Probably not a fit
Patients with prior gallbladder drainage procedures or those with acute cholecystitis will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to evaluate the efficacy of endoscopic transpapillary gallbladder drainage (ETGBD) combined with the insertion of a fully covered self-expanding metal stent in preventing acute cholecystitis in patients with specific anatomical conditions. The study hypothesizes that this approach will reduce the frequency and severity of complications associated with biliary obstruction. Participants will be monitored for the occurrence of cholecystitis and the need for additional invasive procedures. The trial will compare outcomes in patients receiving this intervention against standard care.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the incidence of acute cholecystitis in at-risk patients.
How similar studies have gone: While similar approaches have been explored, this specific combination of ETGBD and fully covered stents is novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Adults 19 years of age or older 2. Patients requiring endoscopic retrograde cholangiography and drainage for therapeutic purposes. 3. Patients with imaging (CT, Cholangiogram) confirmed confluence of the cystic duct with the distal third of the common bile duct. 4. Patients who have voluntary informed consent to participate in the study. Exclusion Criteria: * Patients who have undergone percutaneous/surgical bile duct or gallbladder drainage prior to study enrollment. * Patients with anatomic deformity of the upper gastrointestinal tract after gastric or hepatobiliary surgery * Patients with concomitant gastric/duodenal obstruction * Patients with confirmed or suspected cystic duct obstruction on imaging studies * Patients with acute cholecystitis, acute pancreatitis * Patients who underwent cholecystectomy * Patients with a life expectancy of less than 3 months * Patients who are otherwise unable to undergo endoscopic retrograde cholangiopancreatography
Where it's running
-
Seoul National University Hospital
Seoul, South Korea Recruiting
Study contacts
- Study coordinator: Myeong Hwan Lee, MD.
- Email: dlaudghks01@snu.ac.kr
- Phone: +82-10-7733-6494
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Registry analyzing outcomes of therapeutic endoscopic ultrasound procedures
This study looks at how well therapeutic endoscopic ultrasound works for people with gastrointestinal issues and what factors might affect the results.
-
EUS-guided pancreaticobiliary procedures with the RIVOS access device
This study tests how the RIVOS EUS access device performs during interventional procedures for pancreatic and bile duct problems in adults.
-
Percutaneous vs. Endoscopic Gallbladder Drainage for those who aren’t surgery candidates
This randomized trial tests two less-invasive gallbladder drainage methods to see which works better for people with acute gallbladder infection who aren’t candidates for surgery.
-
Cholecystitis: EUS-guided Gallbladder Drainage vs Cyst removal by LCC in older adults
In people aged 75 and up with acute cholecystitis, this study tests whether an endoscopic drainage procedure (EUS-GBD) works as well as the standard gallbladder removal surgery (LCC).
-
Sedation Methods in PTBD: How Two Regimens Compare for Quality and Recovery
This study tests two sedation plans (propofol with remifentanil vs propofol with ketamine) to see which helps patients recover faster after PTBD while staying comfortable and safe.
-
12-mm Partially Covered vs Bare Self-Expandable Stents for Malignant Distal Biliary Obstruction
This study tests whether a 12-mm partially covered self-expandable stent works better than a 12-mm bare self-expandable stent for patients with unresectable malignant distal biliary obstruction who have already had PTBD.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.